TABLE 1.

Doppler image study in WT and Na/K-ATPase knockdown (α1^+/−) mice with MBG infusion

EDD, end diastolic dimension; ESD, end systolic dimension; BW, body weight; HW, heart weight; LVW, left ventricle weight; SWT, anterior wall thickness; PWT, posterior wall thickness; shortening (%) = (EDD − ESD)/EDD × 100). Data are presented as mean ± S.E. (*, p < 0.05, base line versus 4 weeks).

Variables	WT				α1+/−
	Control		MBG		Control		MBG
	Base line	4 wk	Base line	4 wk	Base line	4 wk	Base line	4 wk
HR (beat/min)	439 ± 11	473 ± 40	453 ± 31	451 ± 26	475 ± 29	492 ± 20	422 ± 29	447 ± 11
EDD (mm)	3.86 ± 0.27	3.75 ± 0.14	3.15 ± 0.27	3.37 ± 0.19	3.77 ± 0.21	3.65 ± 0.16	3.43 ± 0.23	4.29 ± 0.14*
ESD (mm)	2.25 ± 0.18	2.12 ± 0.19	1.61 ± 0.25	2.10 ± 0.14	2.27 ± 0.15	2.23 ± 0.10	1.81 ± 0.26	3.12 ± 0.13*
PWT (mm)	1.05 ± 0.10	1.27 ± 0.16	1.06 ± 0.05	0.99 ± 0.07	0.90 ± 0.07	1.03 ± 0.14	0.92 ± 0.04	0.71 ± 0.04*
SWT (mm)	1.07 ± 0.01	0.94 ± 0.05	1.42 ± 0.14	1.32 ± 0.10	1.03 ± 0.07	0.92 ± 0.04	1.31 ± 0.38	0.78 ± 0.09*
Shortening (%)	41.8 ± 1.7	43.2 ± 4.8	50.4 ± 4.6	39.3 ± 2.5	40.0 ± 1.3	36.5 ± 2.0	47.8 ± 4.2	24.3 ± 4.5*
HW/BW (mg/g)		3.9 ± 0.2		4.0 ± 0.2		3.8 ± 0.1		4.1 ± 0.1
LVW/BW (mg/g)		2.9 ± 0.3		3.0 ± 0.1		3.1 ± 0.1		3.2 ± 0.1