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. 2012 Mar 20;287(20):16699–16708. doi: 10.1074/jbc.M111.315333

FIGURE 2.

FIGURE 2.

CS exposure enhances expression of MMP-9 and MMP-12 at early stage in Fut8+/− mice. Total RNAs from 2-week CS-exposed lungs were used for real-time PCR analysis of MMP-9 (A) and MMP-12 (C). Data are the mean ± S.E. (n = 10). Values were normalized to RPL4 levels and are expressed as the -fold increases against the value for wild-type (Fut8+/+) non-CS-exposed mice. *, p < 0.05; p < 0.01 versus the matched groups connected with bars. The protein expression and/or enzyme activity of MMP-9 (B) and MMP-12 (D) was measured as described under “Experimental Procedures.” Values for MMP-9 are corrected with the activity of commercial recombinant protein and are expressed as the amount of activated MMP-9.