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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Trends Endocrinol Metab. 2011 Nov 1;23(1):32–40. doi: 10.1016/j.tem.2011.09.005

Figure 1.

Figure 1

Crystal structure of SHBG protein. (A) Ribbon representation demonstrating the interaction of the N-terminal domains (residues 13–188) of each SHBG subunit to form the homodimer. The two SHBG N-terminal laminin G-like (LG)-domains, each containing a steroid-binding site, are shown in red and blue. (B) Representation of the domain composition of dimeric full-length SHBG. The steroids bound to the N-terminal LG-domains are depicted as yellow ellipses. The twofold symmetry axis that relates the two monomers in dimeric SHBG is indicated as a vertical line at the center of the sketch. Adapted from Avvakumov et al. [61].