Table 1. Distribution of Cul4b genotypes in progeny of Cul4b +/flox/Cul4b +/null;EIIa-Cre +/− females.
| Group | Wild-Type | Heterozygous | Knockout | Absorbed |
| Cul4b genotype | Cul4b +/+ or Cul4b +/Y | Cul4b +/null | Cul4b null/Y | NDa |
| Expected Mendelian % | 50% | 25% | 25% | - |
| 3 weeks (%) (n = 135) | 107 (79%) | 28 (21%) | 0 (0%) | - |
| 14.5 dpc (%) (n = 61) | 31 (51%) | 11 (18%) | 0 (0%) | 19 (31%) |
| 12.5 dpc (%) (n = 39) | 17 (44%) | 9 (23%) | 0 (0%) | 13 (33%) |
| 10.5 dpc (%) (n = 38) | 19 (50%) | 12 (32%) | 0 (0%) | 7 (18%) |
| 9.5 dpc (%) (n = 31) | 15 (48%) | 7 (23%) | 0 (0%) | 9 (29%) |
| 8.5 dpc (%) (n = 28) | 15 (54%) | 6 (21%) | 7 (25%) | (0%) |
Litters were dissected at the times shown and genotyped by PCR as described in Materials and Methods.
a
ND indicates that the Cul4b genotype could not be determined by PCR.