Table 7. Changes in the levels of transcripts involved in apoptosis pathway.
| |
|
Fold change* |
Fold change* |
Fold change* |
|---|---|---|---|---|
| Gene symbol | Gene name | D vs N | D + mRAGE-Fc vs N | D + PHA666859 vs N |
| Dapl1 |
Death associated protein-like 1 |
2.6 |
1.2 |
1.2 |
| Bid |
BH3 interacting domain death agonist |
1.6 |
1.5 |
1.3 |
| Fads3 |
Fatty acid desaturase 3 |
1.3 |
1.2 |
1.2 |
| Fas |
Fas (TNF receptor superfamily member 6) |
1.3 |
1.1 |
1.2 |
| Bag5 |
BCL2-associated athanogene 5 |
1.2 |
1.2 |
1.4 |
| Traf3ip3 |
TRAF3 interacting protein 3 |
1.5 (down) |
1.5 (down) |
2.5 (down) |
| Tnfsf13 |
Tumor Necrosis Factor superfamily member 13 |
1.4 (down) |
1.5 (down) |
1.6 (down) |
| Tnfrsf18 |
Tumor necrosis factor receptor superfamily, member 18 |
1.4 (down) |
1.7 (down) |
2.2 (down) |
| Casp7 |
Caspase 7 |
1.4 (down) |
1.5 (down) |
2.0 (down) |
| Bcl7c | B-cell CLL/lymphoma 7C | 1.1 (down) | 1.6 (down) | 1.3 (down) |
*D=diabetic control, n=nondiabetic control, D+mRAGE-Fc=diabetic plus murine RAGE-Fc fusion protein, D+PHA666859=diabetic plus p38 MAPK inhibitor PHA666859.