Table 8. Altered levels of transcripts involved in neuronal functions.
| |
|
Fold change* |
Fold change* |
Fold change* |
|---|---|---|---|---|
| Gene symbol | Gene name | D vs N | D + mRAGE-Fc vs N | D + PHA666859 vs N |
| Pcgf2 |
Polycomb group ring finger 2 |
1.5 |
1.3 |
1.2 |
| Slc15a2 |
Solute carrier family 15 (H+/peptide transporter), member 2 |
1.3 |
1.1 |
1.1 |
| Kcnq4 |
Potassium voltage-gated channel, subfamily Q, member 4 |
1.2 |
1.1 |
1.1 (down) |
| Chrna2 |
Cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) |
1.2 |
1.2 |
1.2 |
| Grinl1a |
Glutamate receptor, ionotropic, NMDA like 1A |
1.2 |
2 |
2 |
| Chrm4 |
Cholinergic receptor, muscarinic 4 |
1.04 |
1.2 |
1.4 |
| Slc6a5 |
Solute carrier family 6 (neurotransmitter transporter, glycine), member 5 |
1 |
1.39 (down) |
1.32 (down) |
| Kcnip4 |
Kv channel interacting protein 4 |
1.25 (down) |
1.13 (down) |
1.62 (down) |
| Kcnma1 |
Potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
1.24 (down) |
1.62 (down) |
1.57 (down) |
| Grin1 |
Glutamate receptor, ionotropic, NMDA1 (zeta 1) |
1.21 (down) |
1.79 (down) |
1.47 (down) |
| Chrnb3 |
Cholinergic receptor, nicotinic, beta polypeptide 3 |
1.08 (down) |
1.44 (down) |
1.35 (down) |
| Fez1 | Fasciculation and elongation protein zeta 1 (zygin I) | 1.03 (down) | 1.35 (down) | 1.29 (down) |
*D=diabetic control, n=nondiabetic control, D+mRAGE-Fc=diabetic plus murine RAGE-Fc fusion protein, D+PHA666859=diabetic plus p38 MAPK inhibitor PHA666859.