Table 9. Altered levels of selected photoreceptor-specific transcripts.
| |
|
Fold change* |
Fold change* |
Fold change* |
|---|---|---|---|---|
| Gene symbol | Gene name | D vs N | D + mRAGE-Fc vs N | D + PHA666859 vs N |
| Cngb3 |
Cyclic nucleotide gated channel beta 3 |
1.3 (down) |
1.4 (down) |
1.4 (down) |
| Arr3 |
Arrestin 3, retinal |
1.3 (down) |
1.6 (down) |
1.8 (down) |
| Gnb3 |
Guanine nucleotide binding protein (G protein), beta 3 |
1.3 (down) |
1.7 (down) |
1.8 (down) |
| Pde6h |
Phosphodiesterase 6H, cGMP-specific, cone, gamma |
1.2 (down) |
1.8 (down) |
2.2 (down) |
| Pde6a |
Phosphodiesterase 6A, cGMP-specific, rod, alpha |
1.2 (down) |
1.4 (down) |
1.5 (down) |
| Gnat2 |
Guanine nucleotide binding protein, alpha transducing 2 |
1.1 (down) |
1.3 (down) |
1.2 (down) |
| Crxos1 |
Crx opposite strand transcript 1 |
1.1 (down) |
1.4 (down) |
1.7 (down) |
| Pde6c |
Phosphodiesterase 6C, cGMP specific, cone, alpha prime |
1.1 (down) |
1.7 (down) |
1.8 (down) |
| Nrl |
Neural retina leucine zipper gene |
1.02 (down) |
1.1 |
1.1 |
| Crx |
Cone-rod homeobox containing gene |
1.03 |
1.3 |
1.2 |
| Nr2e3 | Nuclear receptor subfamily 2, group E, member 3 | 1.01 | 1.11 (down) | 1.22 (down) |
*D=diabetic control, n=nondiabetic control, D+mRAGE-Fc=diabetic plus murine RAGE-Fc fusion protein, D+PHA666859=diabetic plus p38 MAPK inhibitor PHA666859.