Table 1. Demographic information on patients and controls of POAG discovery and replication samples.
| Descriptive | Discovery sample POAG cases | Replication sample POAG cases | p-value differences between discovery and replication samples | WTCCC2 controls | Southampton controls |
|---|---|---|---|---|---|
| No. of subjects |
n=387 |
n=294 |
|
n=5380 |
n=50 |
|
Diagnosis | |||||
| POAG |
387 |
294 |
|
NA |
0 (0%) |
| HTG |
319(82%) |
233(79%) |
|
NA |
0 (0%) |
| NTG |
68(18%) |
61(21%) |
p=0.3† |
NA |
0 (0%) |
|
Age in years | |||||
| Mean |
75.3 |
73.1 |
|
NA |
79 |
| Standard deviation |
10.6 |
10.7 |
p=0.0077* |
NA |
4.9 |
|
Gender | |||||
| Female |
193 |
144 |
|
2647 |
27 |
| Male | 194 | 150 | p=0.82† | 2733 | 23 |
This table describes the diagnosis, age and gender of the discovery and replication POAG case and control samples. POAG=primary open-angle glaucoma; HTG=high tension glaucoma, NTG=normal tension glaucoma; p-value *significance of independent samples T- test, †significance of 2×2 χ2 test; NA=not available. WTCCC2=Wellcome Trust Case Control Consortium 2 controls –including 1958 British birth cohort and national blood service cohort members. Southampton Controls –have no sign of Glaucoma or Age-related macular degeneration.