Table 3. Results for the top hit in the POAG GWAS discovery sample, and all nominally significant replication results.

Phenotype	SNP	Location	Nearest gene(s)	Frequency of allele 1 in discovery cases, controls,(allele2)/Qtrait mean direction	Frequency of allele 1 in replication cases, controls,(allele2)/Qtrait mean direction	Discovery p-value	Replication p-value
Most significant GWAS region
POAG	rs11961171	chr6:11384014	NEDD9	A=0.1158, 0.05332 (G)	A=0.04762, 0.06 (G)	8.55E-13	0.5974
POAG	rs967473	chr6:11437409	NEDD9	A=0.1899, 0.1407 (G)	A=0.1382, 0.15 (G)	0.000167	0.7538
POAG	rs9366868	chr6:11811486	C6orf105	A=0.3329, 0.4098 (G)	A=0.4041, 0.49 (G)	2.59E-05	0.1074
Significant at replication
avCCT	rs17128941	chr14:92754850	C14orf130 (UBR7)	T->C increasing CCT	T->C increasing CCT	5.52E-06	0.02743
avCDR	rs4385494	chr8:136919236	KHDRBS3	T->G increasing CDR	T->G increasing CDR	4.51E-05	0.02937
HTG	rs4237260	chr9:75931236	RORB	C=0.3199, 0.233 (G)	C=0.206, 0.35 (G)	4.98E-07	0.001949*
NTG	rs7785999	chr7:32427787	PDE1C, LSM5	A=0.2692, 0.1467 (C)	A=0.09483, 0.1939 (C)	9.22E-05	0.02932*

This table gives the results of the most significant SNPs in the discovery sample and all nominally significant (p<0.05) results in the replication sample, including allele frequencies for risk analyses and direction of effect for quantitative trait analyses. *The effect is in opposite directions in the discovery and replication samples.