Figure 3. Half – life of GSK0660 after topical application to skin.

42 mg of GSK0660 ointment was applied to dorsal skin of C57Bl/6j wild type mice. Mice were sacrificed at the time after drug application indicated in the figure and drug concentration determined by mass spectrometry, as detailed in Methods. Data shown represent average ± s.d. of n = 3 mice per data point.