Fig 4.
Acute MA treatment reduces TH immunoreactivity in lox-P PPARγ/AAV-Cre or WT/AAV-Cre mice. WT and loxP-PPARγ mice were treated with AAV-Cre unilaterally in left nigra area. Striatal tissue in left hemisphere was collected for Western analysis at 2 days after administration of MA or saline. (A) MA treatment significantly reduced striatal TH/actin immunoreactivity in loxP-PPARγ/AAV-Cre and WT/AAV-Cre mice. *p<0.05, 2-way ANOVA. (B) An example of TH and actin Western blotting from mice receiving MA or saline.