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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Cancer Metastasis Rev. 2012 Jun;31(1-2):295–321. doi: 10.1007/s10555-012-9346-z

Fig. 2.

Fig. 2

Identified phospho-DDR1 interactions. The PTB domain in ShcA and the SH2 domain in Csk and Nck2 directly interact with phospho-DDR1. In the case of PLC-γ, Vav1/2, SFKs, and PI3K, which contain both SH2 and SH3 domains, the interacting domain(s) is unknown. TM, transmembrane domain; SH2, Src homology 2 domain; SH3, Src homology 3 domain; PTB, phospho-tyrosine binding domain; PLCγ, phospholipase C γ; ShcA, SH2 containing transforming protein A; Csk, C-terminal Src kinase; SFKs, Src family tyrosine kinases; PI3K, phosphoinositide 3 kinase; SHP-2, SH2 containing protein tyrosine phosphatase 2; SHIP-1/2, SH2-containing inositol polyphosphate 5-phosphatase 1/2, and STATs, Signal transducer and activator of transcription. The indicated amino acid annotations refer to the DDR1b isoform.