Fig. 1.

Organisation of MyBP-C. a Schematic showing the domain architecture of cardiac and skeletal MyBP-C. The protein is composed of repeats of IgI-like and FnIII-like domains. PA-domain refers to the proline–alanine rich linker region while M-domain refers to the 105 residue domain between C1 and C2 also called MyBP-C motif. b Schematic arrangement of cardiac MyBP-C (cMyBP-C) with respect to the components of the sarcomere. Here the C-terminal of cMyBP-C is arranged parallel to the thick filament backbone (Squire et al. 2003), while the N-terminal is shown interacting with a thin filament