Table 3.
Multivariate risk factors for all-cause mortality in 98 HIV-infected patients with cryptococcal meningitis.
| Variable | Adjusted Odds Ratio | 95% CI | P-value |
|---|---|---|---|
| Abnormal mental status | 18.0 | 3.8 – 84 | < 0.001 |
| Symptoms duration | |||
| <14 days | 1.0 | Ref | Ref |
| 15–28 days | 3.9 | 0.7 – 22.5 | 0.12 |
| >28 days | 10.8 | 2.0 – 57.3 | 0.005 |
| CSF WBC count | |||
| ≤ 5 cells/mcL | 4.6 | 1.1 – 18.9 | 0.027 |
| 6–25 cells/mcL | 2.3 | 0.3 – 20.1 | 0.40 |
| >25 cells/mcL | 1.0 | Ref | Ref |
| CNS shunt placement / drainage | 2.8 | 0.6 – 12.8 | 0.19 |
| Increased intracranial pressure | 15.0 | 2.1 –107 | 0.007 |
| Viral load > 50,000 copies/mL | 5.8 | 1.1 – 30 | 0.037 |
| At day 7–14 lumbar puncture 1 | |||
| CSF quantitative yeast count ≥10/mcL (n=89) | 6.9 | 1.1 – 43.0 | 0.038 |
| Opening pressure ≥50 cm H20 (n=14) | 14.6 | 1.7 – 124 | 0.014 |
| Opening pressure not documented (n=35) | 5.7 | 0.5 – 63.4 | 0.154 |
| Opening pressure <50 cm H20 (n=40) | 1.0 | Ref | Ref |
1
Day 7–14 lumbar puncture variables are adjusted for baseline predictors but not vice versa.