Table 3.
In vivo tumourigenicity of SW872 xenograft-derived subpopulations.
| Cells injected | 25 000 | 5 000 | 1000 | 100 |
|---|---|---|---|---|
| Aldefluorhigh CD133high | ND | 2/3 | 4/14 | 2/14 |
| Aldefluorhigh CD133low | 2/12 | 3/16 | 2/14 | 0/14 |
| Aldefluorlow CD133high | 0/6 | 1/16 | 0/18 | 0/16 |
| Aldefluorlow CD133low | 2/14 | 7/14 | 7/18 | 0/14 |
| TRA-1-85+ (Control) | 2/12 | 2/12 | 8/16 | 0/10 |
The table displays the total number of tumors formed, divided by the total number of injections performed. 100 - 25 000 cells of each group were injected subcutaneously into immunodeficient mice. Tumourigenicity was not determined (ND) for 25 000 Aldefluorhigh CD133high cells. TRA-1-85+ represent viable, single SW872 cells. The results are accumulated over three individual experiments.