Table 10.
Quality of life and functional outcomes in randomized controlled trials of APAP versus CPAP
| Study PMID |
Baseline AHI (SD) [eligibility] |
Baseline ESS (SD) | Interventions | Number analyzed | Duration (design) | Outcome | Favors | If significant difference | Dropout (%) | Study quality | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net difference | 95% CI | Test range | P | |||||||||||
| "Worst" | "Best" | |||||||||||||
| Fietze 2007 [11] 17337881 |
42 (26) [≥10] |
nd | APAP | 20 | 1.5 months (XO) |
SF-36 all |
0 | 0 | C | |||||
| CPAP | 21 | |||||||||||||
| Hukins 2004 [19] 15683142 |
56 (nd) [≥5] |
12.5 (nd) | APAP | 46 | 2 months (XO) |
SF-36-M | 0 | 16 | B | |||||
| CPAP | 46 | |||||||||||||
| SF-36-P | 0 | |||||||||||||
| Massie 2003 [22] 12406840 |
nd [≥15] |
nd | APAP | 44 | 1.5 months (XO) |
SF-36 - MH | APAP | 5 | 0.16 to 9.8a | 0 | 100 | < 0.05 | 4 | B |
| CPAP | 44 | SF-36 - vitality | APAP | 7 | 0.6 to 13.4a | 0 | 100 | < 0.05 | ||||||
| SF-36 - remainder |
0 | |||||||||||||
| Meurice 2007 [13] 17638595 |
55 (10) [nd] |
11.8 (4.9) | APAP (AutoSet) | 15 | 3 months (PL) |
SF-36-M | 0 | 15 | B | |||||
| CPAP | 14 | SF-36-P | 0 | |||||||||||
| 6 months (PL) |
SF-36-M | 0 | 15 | |||||||||||
| SF-36-P | 0 | |||||||||||||
| Nussbaumer 2006 [15] 16537862 |
41 (20) [> 10] |
12.7 (3.3) | APAP | 30 | 1 month (XO) |
SF-36 all |
0 | 12 | B | |||||
| CPAP | 30 | |||||||||||||
| Senn 2003 [25] 14525804 |
46 (23) [> 10] |
14.2 (3.8) | APAP (Autoset T) | 29 | 1 month (XO) |
SF-36 all |
0 | 7 | B | |||||
| APAP (AutoAdjust) | 29 | Vigilance (OSLER) | 0 | |||||||||||
| CPAP | 29 | |||||||||||||
| To 2008 [17] 18197915 |
54.3 (nd) [> 30] |
13.4 (nd) | APAP | 41 | 1 month (XO) |
SAQLI | 0 | 5 | B | |||||
| CPAP | 41 | 2 months (XO) |
SAQLI | 0 | ||||||||||
| Vennelle 2010 [30] 20175411 |
33 (18) [≥15] | 14 (3) | APAP | 181 | 6 weeks (XO) | SF-36-M | 0 | 9.5 | A | |||||
| CPAP | 181 | SF-36-P | 0 | |||||||||||
| Vigilance (OSLER) | 0 | |||||||||||||
| Vigilance (Psychomotor) |
0 | |||||||||||||
| West 2006 [33] 16254055 |
33b (nd) [> 10] |
16.5c (nd) | APAP | 28 | 6 months (PL) | SF-36-P | 0 | 9.2 | ||||||
| CPAP (auto) | 31 | SF-36-M | 0 | |||||||||||
| CPAP (algo) | 27 | SF-36-energy, vitality | 0 | |||||||||||
| Vigilance (OSLER) | 0 | |||||||||||||
AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; OSLER: The Oxford Sleep Resistance Test; SAQLI: Sleep Apnea Quality of Life Index; XO: cross-over design. SF-36 M: Short Form Health Survey Mental Health summary measure. SF_36 P: Short Form Health Survey Physical Health summary measure. SF-36 MH: Short Form Health Survey Mental Health scale. aEstimated from reported P value. b> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm. cMedian in algorithm-determined CPAP arm.