Table 2.
Compliance (mean hours/night) in randomized controlled trials of APAP versus CPAP
| Study PMID |
Baseline AHI (SD) [Eligibility] |
Baseline ESS (SD) | Duration (design) | Interventions | Number analyzed | Final | Change (final) |
Net difference or difference |
P | Dropout (%) | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|---|
| d'Ortho 2000 [32] 11035671 |
58 (6) [≥10] |
12.7 (5.3) | 2 months (XO) |
APAP | 25 | 4.1 | -0.6 | -1.5, 0.32a | 0.20 | 0 | B |
| CPAP | 25 | 4.7 | |||||||||
| Damjanovic 2009 [10] 19129293 |
44 (25) [≥15] |
8.8 (5.2) | 3 months (PL) |
APAP | 46 | 5.4 | 0 | -0.7, 0.7 | nd | 8 | B |
| CPAP | 46 | 5.4 | |||||||||
| 9 months (PL) |
APAP | 34 | 5.2 | 0.1 | -0.9, 1.1 | nd | 22 | ||||
| CPAP | 44 | 5.1 | |||||||||
| Fietze 2007 [11] 17337881 |
42 (26) [≥10] |
nd | 1.5 months (PL) |
APAP | 20 | 5.0 | 0.8 | nd | NS | 0 | C |
| CPAP | 21 | 4.2 | |||||||||
| Galetke 2008 [12] 17148931 |
33 (19) [> 10] |
10.3 (5.7) | 2 months (XO) |
APAP | 20 | 6.37 | -0.01 | -0.82, 0.8 | nd | nd | C |
| CPAP | 20 | 6.38 | |||||||||
| Hudgel 2000 [18] 10947032 |
30 (25) [nd] |
16.0 (5.0) | 3 months (XO) |
APAP | 14 | 6.0 | 0.5 | 0.02, 0.98a | < 0.04 | 35 | C |
| CPAP | 19 | 5.5 | |||||||||
| Hukins 2004 [19] 15683142 |
56 (nd) | 12.5 (nd) | 1 to 2 months (XO) |
APAP | 46 | 5.05 | 0.19 | -0.06, 0.44a | 0.14 | 16 | B |
| CPAP | 46 | 4.86 | |||||||||
| Hussain 2004 [20] 15072173 |
47 (36) [> 15] |
11.1 (6.4) | 1 month (XO) |
APAP | 10 | 4.3 | 0.6 | -0.84, 2.04 | nd | 0 | C |
| CPAP | 10 | 3.7 | |||||||||
| Konermann 1998 [31] 9515848 |
38 (14) [> 20] |
nd | 3 to 6 months (PL) |
APAP | 25 | 6.5 | 0.8 | 0.19, 1.41a | < 0.01 | 4 | B |
| CPAP | 23 | 5.7 | |||||||||
| Marrone 2004 [21] 15165530 |
68 (12) [30] |
16.3 (5.0) | 1 month (XO) |
APAP | 22 | 4.9 | 0.5 | -0.26, 1.26 | nd | 0 | C |
| CPAP | 22 | 4.4 | |||||||||
| Massie 2003 [22] 12406840 |
nd [≥15] |
nd | 1.5 months (XO) |
APAP | 44 | 5.1 | 0.58 | 0.18, 0.99a | 0.005 | 4 | B |
| CPAP | 44 | 4.52 | |||||||||
| Meurice 2007 [13] 17638595 |
55 (10) [nd] |
11.8 (4.9) | 3 months (PL) |
APAP (AutoSet) | 15 | 6.0 | -0.1 | -0.79, 0.59 | nd | 15 | B |
| CPAP | 14 | 6.1 | |||||||||
| 6 months (PL) |
APAP (AutoSet) | 15 | 6.1 | -0.4 | -1.28, 0.48 | nd | 15 | ||||
| CPAP | 14 | 6.5 | |||||||||
| Nolan 2007 [14] 17326544 |
15 (8) [≥5] |
12.3 (4.0) | 2 months (XO) |
APAP | 29 | 4.9 | 0 | nd | 0.94 | 15 | B |
| CPAP | 29 | 4.9 | |||||||||
| Noseda 2004 [23] 15249439 |
51 (25) [> 20] | 10.7 (2.4) | 2 months (XO) |
APAP | 24 | 5.3 | -0.2 | -0.89, 0.49 | nd | 11 | B |
| CPAP | 24 | 5.5 | |||||||||
| Nussbaumer 2006 [15] 16537862 |
41 (20) [> 10] |
12.7 (3.3) | 1 month (XO) |
APAP | 30 | 5.1 | 0.3 | -0.29, 0.89 | nd | 12 | B |
| CPAP | 30 | 4.8 | |||||||||
| Patruno 2007 [16] 17494789 |
46 (14) [> 20] |
15 (2.7) | 3 months (PL) |
APAP | 15 | 6.2 | 0.2 | -0.25, 0.65 | nd | 23 | C |
| CPAP | 16 | 6.0 | |||||||||
| Planes 2003 [29] 12683473 |
59 (17) [≥30] |
15.1 (3.9) | 2 months (PL) |
APAP | 16 | 4.5 | -0.8 | nd | NS | 14 | C |
| CPAP | 14 | 5.3 | |||||||||
| Randerath 2001 [26] 11254519 |
35 (26) [≥10] |
11.1 (5.1) | 1.5 months (XO) |
APAP | 46 | 5.26 | 0 | -0.44, 0.44 | nd | 12 | B |
| CPAP | 46 | 5.26 | |||||||||
| Resta 2004 [24] 15679008 |
47 (11) [> 30] |
13.9 (3.2) | 1 month (PL) |
APAP | 10 | 5.2 | -0.1 | -1.12, 0.92 | nd | 0 | C |
| CPAP | 10 | 5.3 | |||||||||
| Senn 2003 [25] 14525804 |
46 (23) [> 10] |
14.2 (3.8) | 1 month (XO) |
APAP (Autoset T) | 29 | 5.5 | -0.1 | nd | NS | 7 | B |
| APAP (AutoAdjust) | 29 | 5.5 | -0.1 | nd | NS | ||||||
| CPAP | 29 | 5.6 | |||||||||
| Sériès 1997 [27] 9341056 |
44 (20) [nd] |
15.5 (4.5) | 0.75 months (PL) |
APAPb | 12 | ndc | - | - | NS | 0 | C |
| CPAP | 12 | nd | |||||||||
| APAPd | 12 | ndc | - | - | NS | ||||||
| CPAP | 12 | nd | |||||||||
| Vennelle 2010 [30] 20175411 |
33 (18) [≥15] | 14 (3) | 6 weeks (XO) | APAP | 181 | 4.2 | 0.2 | 0.003, 0.397 | 0.047 | 9.5 | A |
| CPAP | 181 | 4.0 | |||||||||
| Teschler 2000 [28] 10885414 |
53 (26) [> 20] |
nd | 2 months (XO) |
APAP | 10 | 6.3 | 0.2 | -0.7, 1.1 | nd | nd | C |
| CPAP | 10 | 6.1 | |||||||||
| To 2008 [17] 18197915 |
54 (nd) [> 30] |
13.4 (nd) | 1 month (XO) |
APAP | 41 | 4.3 | 0.5 | 0.02, 0.98 | 0.04 | 5 | B |
| CPAP | 41 | 3.8 | |||||||||
| 2 months (XO) |
APAP | 41 | 4.4 | 0.7 | 0.17, 1.23a | 0.01 | |||||
| CPAP | 41 | 3.7 | |||||||||
| West 2006 [33] 16254055 |
33e (nd) [> 10] |
16.5f (nd) | 1 month (PL) |
APAP | 29 | 5.3 | 0.27 | 6.1 | A | ||
| CPAP (auto) | 31 | 4.3 | |||||||||
| CPAP (algo) | 32 | 4.7 | |||||||||
| 6 months (PL) |
APAP | 28 | 5.5 | 0.23 | |||||||
| CPAP (auto) | 31 | 4.9 | |||||||||
| CPAP (algo) | 27 | 4.0 | 9.2 |
AHI: apnea-hypopnea index (events/hour); algo: fixed pressure CPAP determined by algorithm; APAP: auto-titrating CPAP; auto: fixed pressure CPAP determined by pressures from 1 week of APAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported P value. bEstimated effective pressure. cDirections of changes not reported in the study. dMeasured effective pressure. e> 4% SaO2 dip rate per hour in algorithm-determined CPAP arm, median. fMedian in algorithm-determined CPAP arm.