Table 5.
Arousal index (events/hour) in randomized controlled trials of APAP versus CPAP
| Study PMID |
Baseline AHI (SD) [eligibility] |
Baseline ESS (SD) | Duration (design) | Interventions | Number analyzed | Baseline (SD) | Change (final) |
Net difference or difference |
95% CIa | P | Dropout (%) | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| d'Ortho 2000 [32] 11035671 |
58 (6) [≥10] |
12.7 (5.3) | 2 months (XO) |
APAP | 25 | 45.6 (25.8) |
-30.1 | 1.8 | nd | NS | 0 | B |
| CPAP | 25 | 45.6 (25.8) |
-31.9 | |||||||||
| Damjanovic 2009 [10] 19129293 |
44 (25) [≥15] |
8.8 (5.18) | 3 months (PL) |
APAP | 46 | 30.6 (22.4) | -18.3 | -0.2 | -7.92 to 7.52 | nd | 8 | B |
| CPAP | 46 | 34.5 (21.0) |
-18.1 | |||||||||
| 9 months (PL) |
APAP | 34 | 30.6 (22.4) | -17.7 | 3.6 | -4.09 to 11.29 | nd | 22 | ||||
| CPAP | 44 | 34.5 (21.0) |
-21.3 | |||||||||
| Galetke 2008 [12] 17148931 |
33 (19) [> 10] |
10.3 (5.7) | 2 months (XO) |
APAP | 20 | 17.6 (9.2) | -4.0 | 1.0 | -2.52 to 4.52 | nd | nd | C |
| CPAP | 20 | 17.6 (9.2) | -5.0 | |||||||||
| Hussain 2004 [20] 15072173 |
47 (36) [> 15] |
11.1 (6.4) | 1 month (XO) |
APAP | 10 | 17.3 (17.7) | -11.4 | 1.0 | -2.5 to 4.5 | nd | 0 | C |
| CPAP | 10 | 17.3 (17.7) | -12.4 | |||||||||
| Konermann 1998 [31] 9515848 |
38 (14) [> 20} |
nd | 3 to 6 months (PL) |
APAP | 25 | 16.9 (10.5) | -9.5 | -3.3 | -6.6 to 0b | < 0.05 | 4 | B |
| CPAP | 23 | 13.3 (13.3) |
-6.2 | |||||||||
| Nolan 2007 [14] 17326544 |
15 (8) [≥5) |
12.3 (4) | 2 months (XO) |
APAP | 29 | 16.0 (14.0) | -14.0 | -3.0 | -5.7 to -0.29b | 0.03 | 15 | B |
| CPAP | 29 | 16.0 (14.0) | -11.0 | |||||||||
| Planes 2003 [29] 12683473 |
59 (17) [≥30] |
15.1 (3.9) | 2 months (PL) |
APAP | 16 | 44.4 (19.1) | 3.3 | -7.14 to 12.74 | nd | 14 | C | |
| CPAP | 14 | 48.5 (14.2) | ||||||||||
| Randerath 2001 [26] 11254519 |
35 (26) [≥10] |
11.1 (5.1) | 1.5 months (XO) |
APAP | 52 | 34 (21.7) | -23.1 | -1.7 | -3.7 to 0.3 | nd | 12 | B |
| CPAP | 52 | 34 (21.7) | -21.4 | |||||||||
| Resta 2004 [24] 15679008 |
47 (11) [> 30] |
13.9 (3.2) | 1 month (PL) |
APAP | 10 | 43.1 (11.9) | -35.7 | 0.1 | -8.29 to 8.49 | nd | 0 | C |
| CPAP | 10 | 43.1 (9.1) | -35.8 | |||||||||
| Sériès 1997 [27] 9341056 |
44 (20) [nd] |
15.5 (4.5) | 0.75 months (PL) |
APAPc | 12 | nd | nd | - | - | NS | 0 | C |
| CPAP | 12 | nd | nd | |||||||||
| APAPd | 12 | nd | nd | - | - | NS | ||||||
| CPAP | 12 | nd | nd |
AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dMeasured effective pressure.