Table 8.
Rapid eye movement sleep (%) in randomized controlled trials of APAP versus CPAP
| Study PMID |
Baseline AHI (SD) [eligibility] |
Baseline ESS (SD) | Duration (design) | Interventions | Number analyzed | Baseline (SD) | Change (final) |
Net difference or difference |
95% CIa | P | Dropout (%) | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| d'Ortho 2000 [32] 11035671 |
58 (6) [≥10] |
12.7 (5.3) | 2 months (XO) |
APAP | 25 | 16 (5) |
5 | -1 | nd | nd | 0 | B |
| CPAP | 25 | 16 (5) |
6 | |||||||||
| Hussain 2004 [20] 15072173 |
47 (36) [> 15] |
11.1 (6.4) | 1 month (XO) |
APAP | 10 | 15 (7.0) | 4.0 | -1 | -4.72 to 2.72 | nd | 0 | C |
| CPAP | 10 | 17.6 (5.1) | 2.0 | |||||||||
| Konermann 1998 [31] 9515848 |
38 (14) [> 20] |
nd | 3 to 6 months (PL) |
APAP | 25 | 8.2 (8.1) |
11.9 | 7.1 | nd | NS | 4 | B |
| CPAP | 23 | 5.4 (6.0) |
4.8 | |||||||||
| Meurice 2007 [13] 17638595 |
55 (10) [nd] |
11.8 (4.9) | 6 months (PL) |
APAP (AutoSet) | 15 | 18.9 (6.6) | -2.4 | -2.9 | -7.49 to 1.69 | nd | 15 | B |
| CPAP | 14 | 19.1 (5.9) |
0.5 | |||||||||
| Nolan 2007 [14] 17326544 |
15 (8) [≥5) |
12.3 (4) | 2 months (XO) |
APAP | 29 | 17.6 (5.1) | -0.5 | -2.5 | -5.11 to 0.11b | 0.06 | 15 | B |
| CPAP | 29 | 17.6 (5.1) | 2.0 | |||||||||
| Planes 2003 [29] 12683473 |
59 (17) [≥30] |
15.1 (3.9) | 2 months (PL) |
APAP | 16 | 12.4 (7.0) |
4.2 | 0.5 | -5.44 to 6.44 | nd | 14 | C |
| CPAP | 14 | 13.7 (9.3) | 3.7 | |||||||||
| Randerath 2001 [26] 11254519 |
35 (26) [≥10] |
11.1 (5.1) | 1.5 months (XO) |
APAP | 52 | 11 (8) | 6.0 | 1 | -0.63 to 2.63 | nd | 12 | B |
| CPAP | 52 | 11 (8) | 5.0 | |||||||||
| Resta 2004 [24] 15679008 |
47 (11) [> 30] |
13.9 (3.2) | 1 month (PL) |
APAP | 10 | 15.0 (8.1) |
6.7 | -2 | -10.31 to 6.31 | nd | 0 | C |
| CPAP | 10 | 15.9 (4.2) | 8.7 | |||||||||
| Sériès 1997 [27] 9341056 |
44 (20) [nd] |
15.5 (4.5) | 0.75 months (PL) |
APAPc | 12 | nd | ndd | - | - | NS | 0 | C |
| CPAP | 12 | nd | nd | |||||||||
| APAPe | 12 | nd | ndd | - | - | NS | ||||||
| CPAP | 12 | nd | nd |
AHI: apnea-hypopnea index (events/hour); APAP: auto-titrating CPAP; CPAP: continuous positive airway pressure; ESS: Epworth Sleepiness Scale; nd: no data; NS: non-significant; PL: parallel design; XO: cross-over design. aEstimated from reported data. bEstimated from reported P value. cEstimated effective pressure. dDirections of changes not reported in the study. eMeasured effective pressure.