Table 1.
Karyotypes of cytogenetically abnormal tumors previously diagnosed as MFH of bone.
| Case No.1 | Age/Sex | Diagnosis2 | Site | Karyotype3 | FISH4 |
|---|---|---|---|---|---|
| Case 63 + 64 | 61/M | Myoepithelioma-like sarcoma | Humerus | 42, XY, der(1)t(1;10)(p11;q11), +dic(1;15)(p13;q26), add(6)(p11),-7, add(7)(p22), t(8;9)(q22;p24),-10, add(10)(q11), add(12)(q24),-15, +add(16)(p13),-17, add(19)(p13),-20, -20, r(21)(p13q22), r(22)(p13q13), +1-2mar |
EWSR1-, FUS- |
| Case 69 | 49/M | Myoepithelioma-like sarcoma | Tibia | 77-94 < 4n >, X,-X, del(X)(q21),-Y, add(1) (q25), del(2)(p14)x2,-3,-4, der(4)t(4;5) (q?31;q?15),-5,-5,-6,-8,-8,-9,-9,-9,-9, -10,-10, add(11)(q13)x2, add(12) (q22)x2,-13,-15,-16, add(16)(p13),-17, -17,-17,-17,+18,-19, add(20)(p13)x4, -21,-21, inc |
EWSR1-, FUS- |
| Case 88 | 70/F | Myoepithelioma-like sarcoma | Femur | 54-58 < 2n >, XX,+der(1;9)(q10;q10), +i(5)(p10),+add(6)(q13),+7,+del(8) (q21-22)x2,-9,+15,+20,+20,+20,+22, +22,+3-4 mar |
Failure |
| Case 89 | 53/M | Leiomyosarcoma | Femur (bone infarct) |
58-61, XX,-Y,+i(1)(q10),-3,-4,-5,-6, +add(7)(q11), add(9)(p21)x2,-10,-10, -11, i(11)(p10),-12, add(12)(p13)x2, -13,-14, i(15)(q10),-16,-17,-17, add(19) (q13),+20,+i(20)(p10),-21, der(21) t(1;21)(p13;p11),-22,+2-4mar |
ND |
| Case 985 | 47/M | Leiomyosarcoma | Os ileum | 130-190 < 6n-8n >, X?inc | ND |
| Case 68 | 76/F | UPS with incomplete myogenic differentiation | Femur | 59-113, X?, inc/46, XX, inv(9)(p11q12)c | ND |
| Case 66 | 68/F | UPS | Tibia | 84-106 < 5n >, XX,-X,-X,-X,?add(1) (q42), del(1)(p11), del(1)(q12), der(1) add(1)(q42)del(1)(p11), der(1)add(1) (q44)add(1)(p11)hsr(?), add(2)(q3?3), i(3)(p10),-4, der(4)add(4)(p16)hsr(4) (p16), i(5)(q10),+add(6)(q11)x2,-7, der(8)t(1;8)(p22;p2?3)x1-2, i(10)(q10), -13,-13, add(13)(p11),-14, add(14)(p11), ?i(14)(q10),-15,-15,-16,-16,-17,-17, ?add(17)(p11),-18,-18, der(18)add(18) (p11)hsr(?),-19,-21,-21,-22,?add(22) (q13), inc |
ND |
| Case 105 | 66/F | UPS | Unknown | 67-77, XX,-X,+1,-2, add(2)(p11)x2,-3, +4,-8,-8,+9, dic(9;17)(p21;p13)x2,+10, +12,+13, der(14)t(2;14)(q11;p11),+16, +17,+19,-20,-22 |
ND |
| Case 100 | 52/F | Osteosarcoma | Os ischium | 32-44, X,-X, add(1)(p11),-3,-4,-6,-9,-10, der(12)add(12)(p12)del(12)(q22),-13, -13,-14,-15,-16,-17,-18,-19,-21, add(21) (p11),-22, der(22)t(3;22)(p11;q11) |
ND |
| Case 86 + 94 | 51/M | SCS NOS (metastatic carcinoma?) |
Femur | 44-48, XY, der(1)t(1;18)(p36;q11), del(4)(p15), del(7)(q22), del(8)(p11), dic(8;10)(p11;p?),-13,-15, del(16)(q22), add(19)(p13), add(20)(q13),+add(21) (q22),+r,+1-7mar/80-83, idemx2 |
ND |
| Case 91 | 29/M | Dubious biphasic sarcoma | Humerus Lung met. |
47, XY, add(19)(q13),+mar 88-90, XXYY, der(2)t(2;7)(p21;q11)x2, -4,-4,+i(5)(p10)x2,-7,-7,-12, del(12) (q22)x2, add(13)(q22)x2,+18,-21,-21, +3-4 mar |
ND |
1Case numbers are identical to those in the publication by Romeo et al. [6].
2All tumors were classified as grade 3 tumors (3-grade scale). UPS = undifferentiated pleomorphic sarcoma; SCS NOS = spindle cell sarcoma not otherwise specified.
3All karyotypes are composite karyotypes.
4ND = not done.
5Karyotype on sample obtained after chemotherapy.