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Locations of mutations in the structure of the CA hexamer. (A) Top and side views of a CA hexamer showing E45 (green) and R132 (yellow) side chains from the NMR structure of CA151 (PDB ID: 3H47). (B) Same views, highlighting P38 and T216. P38 (red) in helix 2 is located at the CA NTD-NTD interface and is adjacent to helix 3 in the adjacent subunit. T216 (blue) in helix 11 is near the CA NTD-CTD interface and is close to helix 7 in the nearby subunit.
