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Rescue of P38A and E45A infectivity defects mutations by second-site mutations T216I and R132T. Single-cycle infectivity was assayed in HeLa-P4 target cells. Infectivity was determined as the number of infected cells per ng of p24 in the inoculum, and values are expressed as percentage of wild-type HIV-1 infectivity. Results shown are the mean values of three independent experiments, with error bars representing one standard deviation.
