Table 2.
Immunoexpression of Notch receptors and ligand proteins in calcifying cystic odontogenic tumors (n = 5)
| CCOT components | Notch1 | Notch2 | Notch3 | Notch4 | Jagged1 | Jagged2 | Delta1 |
|---|---|---|---|---|---|---|---|
| Basal pre-ameloblast-like cells | + | - | - | + | - | - | - |
| Suprabasal stellate reticulum-like cells | + | - | - | + | + | - | - |
| Transitory squamous cells | + | - | - | + | + | - | |
| Ghost cells | 2+ | - | - | + | 3+ | - | - |
| Calcifications | + | - | + | + | + | - | - |
| Connective tissue stroma | - | - | + | + | - | - | - |
| Dentinoid | NA | NA | NA | NA | NA | NA | NA |
| Odontome | NA | NA | NA | NA | NA | NA | NA |
CCOT, Calcifying cystic odontogenic tumor; -, negative; +, mild (< 25% positivity); 2+, moderate (25-50% positivity); 3+, strong (> 50% positivity); NA, Not available