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. 2012 Jun;53(6):1093–1105. doi: 10.1194/jlr.M024398

Fig. 3.

Fig. 3.

JNK/c-Jun pathway is involved in PAEC proliferation induced by EETs, but not ERK or p38 MPAK. A: The protective effect of EETs on cell viability was weakened by adding Sp600125 in PAECs (n = 6, *P < 0.05). B: BrdU incorporation assay and PCNA protein expression were examined after using a JNK inhibitor in PAECs (n = 3, *P < 0.05). C: EET-induced proliferation was not mediated by the ERK or p38 MAPK pathway (n = 3, *P < 0.05). D: BrdU incorporation and PCNA expression were studied after overexpression of CYP2J2 in PAECs (n = 3, *P < 0.05). E: EETs increased the cell viability and BrdU incorporation in the presence of 100 μM albumin in PAECs, which was attenuated by Sp600125 (*P < 0.05). F: EETs induced the PCNA expression through JNK pathway even after incubation with 100 μM albumin (n = 3, *P < 0.05).