TABLE 2.
Analyses of contributing factors for CETP activity and HDL-cholesterol level
| CETP Activity (nmol3 H-CE/mg/h) |
HDL-C (mmol/l) |
|||
| β ± SE | P | β ± SE | P | |
| Total (n = 240) | ||||
| ApoE-epsilon | 0.0804 ± 0.0419 | 0.056 | −0.0221 ± 0.0413 | 0.593 |
| CETP-Taq1b | −0.0237 ± 0.0317 | 0.455 | −0.0039 ± 0.0348 | 0.910 |
| ApoC1-Hpa1 | −0.0458 ± 0.0426 | 0.284 | −0.0405 ± 0.0468 | 0.388 |
| BMI | 0.0055 ± 0.0048 | 0.250 | −0.018 ± 0.0053 | 0.001 |
| ApoC1 mass | −0.0031 ± 0.0014 | 0.031 | 0.0037 ± 0.0016 | 0.020 |
| Normolipidemia (n = 101) | ||||
| ApoE-epsilon | 0.0927 ± 0.0509 | 0.070 | −0.035 ± 0.0684 | 0.605 |
| CETP-Taq1b | −0.0154 ± 0.0493 | 0.754 | −0.0008 ± 0.0663 | 0.990 |
| ApoC1-Hpa1 | −0.04 ± 0.0684 | 0.555 | −0.1325 ± 0.092 | 0.151 |
| BMI | −0.0093 ± 0.0086 | 0.281 | −0.0225 ± 0.0116 | 0.053 |
| ApoC1 mass | −0.0078 ± 0.0024 | 0.002 | 0.009 ± 0.0033 | 0.007 |
| Hypercholesterolemia (n = 63) | ||||
| ApoE-epsilon | 0.0764 ± 0.0744 | 0.307 | 0.0321 ± 0.0713 | 0.653 |
| CETP-Taq1b | −0.0146 ± 0.0577 | 0.801 | −0.068 ± 0.0553 | 0.222 |
| ApoC1-Hpa1 | −0.0969 ± 0.0787 | 0.221 | 0.0233 ± 0.0754 | 0.758 |
| BMI | 0.0114 ± 0.0082 | 0.170 | −0.0097 ± 0.0079 | 0.223 |
| ApoC1 mass | −0.0029 ± 0.0023 | 0.214 | 0.0037 ± 0.0022 | 0.102 |
| Hypertriglyceridemia (n = 34) | ||||
| ApoE-epsilon | −0.02 ± 0.1348 | 0.883 | 0.0549 ± 0.1117 | 0.624 |
| CETP-Taq1b | −0.0221 ± 0.0936 | 0.814 | −0.1162 ± 0.0776 | 0.138 |
| ApoC1-Hpa1 | 0.0243 ± 0.1101 | 0.826 | 0.0687 ± 0.0913 | 0.453 |
| BMI | −0.004 ± 0.0119 | 0.740 | −0.0073 ± 0.0099 | 0.461 |
| ApoC1 mass | −0.0023 ± 0.0045 | 0.604 | 0.0023 ± 0.0037 | 0.539 |
| Combined hyperlipidemia (n = 42) | ||||
| ApoE-epsilon | 0.0181 ± 0.1051 | 0.864 | −0.0466 ± 0.0805 | 0.564 |
| CETP-Taq1b | −0.0359 ± 0.0856 | 0.676 | 0.0579 ± 0.0656 | 0.380 |
| ApoC1-Hpa1 | 0.0617 ± 0.1129 | 0.586 | −0.0038 ± 0.0865 | 0.965 |
| BMI | 0.0108 ± 0.0142 | 0.449 | −0.0158 ± 0.0108 | 0.149 |
| ApoC1 mass | 0.0002 ± 0.0041 | 0.955 | −0.0022 ± 0.0031 | 0.481 |
Multiple linear regression analysis was performed. The dependent variable was CETP activity or HDL-C level. Genotypes were encoded as ordinal variables: for apoE-epsilon genotypes, E2E2 + E2E3 = 3, E3E3 = 2, E4E4 + E4E3 = 1; for ApoC1 HpaI genotypes, H1H1 = 3, H1H2 = 2, H2H2 = 1; and for CETP TaqIB genotypes, B1B1 = 3, B1B2 = 2, B2B2 = 1. Statistically significant relationships are presented with bold values.