Table 1. Case description, sphere formation, and tumorigenic activity of CD44+ and CD54+ gastric cancer cells.
| Case | Sex/age | Site | Grade | CD44+CD54+ expression (%) | Sphere formation | Tumor formation |
Secondary tumor formation | ||
|---|---|---|---|---|---|---|---|---|---|
| CD44+CD54+ 1 | Slice (cm3) 2 | Total cell | |||||||
| 1 | F/71 | Pyloric | Moderate | 0.4 | No | 103 (0/3) | 0.05 (2/3) | 3 × 106 (0/3) | N/A |
| 2 | M/60 | Cardial | Moderate | 1.8 | Yes | 103 (3/3) | 0.06 (3/3) | 3 × 106 (2/3) | Yes |
| 3 | F/61 | Corpus | Moderate | 0.6 | No | 103 (0/3) | 0.07 (1/3) | 3 × 106 (0/3) | N/A |
| 4 | M/41 | Pyloric | Poor | 1.3 | Yes | 103 (3/3) | 0.05 (2/3) | 3 × 106 (2/3) | Yes |
| 5 | F/62 | Cardial | Moderate | 7.0 | Yes | 103 (3/3) | 0.05 (3/3) | 3 × 106 (3/3) | Yes |
| 6 | M/55 | Pyloric | Moderate | 0.2 | No | 103 (0/3) | 0.07 (2/3) | 3 × 106 (0/3) | N/A |
| 7 | M/53 | Cardial | Moderate with signet-ring cell | 0.8 | Yes | 103 (3/3) | 0.075 (2/3) | 3 × 106 (2/3) | Yes |
| 8 | M/62 | Corpus | Poor | 19.7 | Yes | 103 (3/3) | 0.06 (3/3) | 3 × 106 (1/3) | Yes |
| 9 | M/76 | Fundus | Moderate | 6.1 | Yes | 103 (3/3) | 0.07 (3/3) | 2 × 106 (3/3) | Yes |
| 10 | F/72 | Pyloric | Moderate | 1.2 | No | 103 (0/3) | 0.075 (3/3) | 3 × 106 (0/3) | N/A |
| 11 | F/59 | Pyloric | Moderate with signet-ring cell | 2.2 | Yes | 103 (3/3) | 0.068 (2/3) | 2 × 106 (2/3) | Yes |
| 12 | F/56 | Pyloric | Moderate with signet-ring cell | 1.5 | Yes | 103 (3/3) | 0.056 (3/3) | 2 × 106 (1/3) | Yes |
| 13 | M/58 | Cardial | Moderate | 0.1 | Yes | 103 (3/3) | 0.07 (3/3) | 2 × 106 (1/3) | Yes |
| 14 | M/55 | Cardial | Moderate | 0.1 | No | 103 (0/3) | 0.06 (2/3) | 3 × 106 (0/3) | N/A |
| 15 | M/77 | Angular notch | Moderate with signet-ring cell | 2.3 | Yes | 103 (3/3) | 0.05 (2/3) | 2 × 106 (2/3) | Yes |
| 16 | M/72 | Angular notch | Moderate | 0.2 | No | 103 (0/3) | 0.07 (3/3) | 3 × 106 (0/3) | N/A |
| 17 | M/41 | Pyloric | Moderate with signet-ring cell | 0.7 | Yes | 103 (3/3) | 0.075 (3/3) | 2 × 106 (2/3) | Yes |
| 18 | M/71 | Angular notch | Moderate with signet-ring cell | 0.6 | Yes | 103 (3/3) | 0.05 (2/3) | 2 × 106 (2/3) | Yes |
1Number of CD44+CD54+ cells injected into mice (number of mice that have tumor formation in three mice).
2Volume of tissue directly cut from tumor (number of mice that have tumor formation in three mice). N/A: not available.