Table 1.
A. N-Alb-P; median Low |
4.3 mg High |
High vs. Low | B. Stones Absent |
Present | C. All Present vs. Absent |
Mean | Range | Normal1 | ||
---|---|---|---|---|---|---|---|---|---|---|
N+ | ≤Median | >Median | p | p | ||||||
Urine | ||||||||||
Total protein; mg | 187 | 3.3 (0.2); 94 | 13 (2); 93++ | < 0.001x | 6.2 (0.5); 94++ | 9.7 (2.1); 93++ | 0.24x | 7.93 | 0.8-161 | < 50 |
N-Alb-P; mg | 187 | 1.7 (0.4); 94++ | 11 (1.9); 93 | < 0.001x | 5.1 (0.4); 94 | 7.3 (2.1); 93 | 0.19x | 6.19 | 0-161 | < 7.0 |
Cr*-Clearance; ml/min | 187 | 108 (2); 94 | 115 (3); 93 | 0.03 | 112 (3); 94 | 111 (2); 93 | 0.44 | 111 | 41-187 | > 50 |
103 × FE-N-Alb-P; % | 187 | 0.90 (0.0); 94 | 3.4 (0.5); 93 | < 0.001 | 1.8 (0.0); 94 | 2.7 (0.0); 93 | 0.13x | 2.2 | 0.08-45 | |
Volume; ml | 187 | 161 (11); 94 | 290 (17); 93 | < 0.001 | 229 (15); 94 | 221 (16); 93 | 0.25x | 225 | 60-720 | 50-600 |
Na; mM | 187 | 10 (0.4); 94 | 15 (0.8); 93 | < 0.001 | 13 (0.6); 94 | 12 (0.7); 93 | 0.43 | 12.5 | 2-47 | < 20 |
K; mM | 187 | 6.7 (0.2); 94 | 9.0 (0.3); 93 | < 0.001 | 7.8 (0.3); 94 | 7.9 (0.3); 93 | 0.41 | 7.8 | 1.8-17 | 2-8 |
Ca; μM | 187 | 298 (19); 93 | 334 (16); 94 | 0.07x | 307 (17); 94 | 325 (18); 93 | 0.23x | 316 | 29-1261 | < 625 |
Mg; μM | 187 | 231 (10); 94 | 277 (10); 93 | 0.002 | 257 (10); 93 | 250 (12); 94 | 0.34 | 253 | 48-776 | > 280 |
Pi; mM | 187 | 1.15 (0.06); 94 | 1.23 (0.07); 93 | 0.22x | 1.19 (0.06); 94 | 1.19 (0.07); 93 | 0.47x | 1.19 | 0.10-3.9 | < 3 |
Ox; μM | 179 | 22 (1.4); 88 | 23 (2.1); 91 | 0.34 | 23 (1); 89 | 24 (2); 90 | 0.32 | 22 | 1.3-193 | < 37 |
Cit; μM | 185 | 253 (13); 93 | 311 (14); 92 | 0.001 | 290 (14); 93 | 272 (13); 92 | 0.16 | 279 | 44-732 | > 132 |
pH | 187 | 5.92 (0.09); 94 | 6.35 (0.07); 93 | < 0.001 | 5.95 (0.08); 94 | 6.33 (0.07); 93 | < 0.001 | 6.14 | 4.4-7.6 | 5.2-7.9 |
General features | ||||||||||
Age; y | 187 | 42 (1.2); 94 | 41 (1.2); 93 | 0.25 | 41 (1.2); 94 | 42 (1.2); 93 | 0.29 | 41.6 | 21-67 | > 22 |
ASFP; score | 187 | 35 (4); 94 | 40 (4); 93 | 0.18 x | 34 (4); 94 | 41 (4); 93 | 0.08x | 36 | 1-271 | 1 |
Renal stones; Absent/Present | 187 | 47/47; 94 | 46/47; 93 | 94/0 | 0/93 | |||||
Systolic blood pressure; mmHg | 152 | 126 (2); 78 | 132 (3); 74 | 0.004 | 129 (2); 75 | 129 (3); 77 | 0.44 | 129 | 90-220 | ≤130 |
Diastolic blood pressure; mmHg | 152 | 82 (1); 78 | 86 (2); 74 | 0.03 | 83 (1); 75 | 84 (2); 77 | 0.32 | 84 | 60-150 | ≤80 |
BMI; kg/(m)2 | 187 | 26.4 (0.3); 94 | 26.2 (0.4); 93 | 0.39 | 26.2 (0.3); 94 | 26.5 (0.4); 94 | 0.25 | 26.3 | 19-40 | ≤25 |
P**-Insulin; μU/ml | 184 | 17 (1); 92 | 16 (1); 92 | 0.26 | 16 (1); 91 | 17 (1); 93 | 0.36 | 16 | 1-83 | < 20 |
P-K; mM/l | 106 | 4.2 (0.03); 62 | 4.2 (0.05);44 | 0.46 | 4.2 (0.04); 49 | 4.2 (0.04); 57 | 0.43 | 4.2 | 3.6-5.1 | 3.8-5.0 |
U**-Hypoxanthine; μM | 75 | 9.9 (0.8); 29 | 13 (0.7); 46 | < 0.001x | 11.5 (0.8); 39 | 12.7 (0.8); 36 | 0.08x | 12.1 | 2.8-25 | < 30 |
U-Xanthine; μM | 75 | 4.0 (0.4); 29 | 7.8 (0.5); 46 | < 0.001x | 6.4 (0.6); 39 | 6.3 (0.5); 36 | 0.45x | 6.3 | 1.2-17 | > 3 |
U-Uric acid; μM | 187 | 357 (16); 94 | 433 (14); 93 | < 0.001 | 403 (12); 94 | 386 (18); 93 | 0.21x | 395 | 44-1351 | < 400 |
U-FE-Uric acid; % | 186 | 7.4 (0.3); 94 | 8.8 (0.4); 92 | < 0.001 | 8.3 (0.3); 94 | 7.8 (0.4); 92 | 0.16 | 8.1 | 0.7-24 | < 11 |
P-Uric acid; μM/l | 187 | 374 (7); 94 | 342 (7); 93 | < 0.001 | 353 (7); 94 | 363 (7); 93 | 0.17 | 358 | 160-631 | < 446 |
P-TAS; mM/l | 57 | 1.37 (0.02); 21 | 1.31 (0.01); 36 | 0.007 | 1.34 (0.02); 30 | 1.32 (0.02); 27 | 0.20 | 1.33 | 1.18-1.49 | 1.29-1.61 |
U-MDA; nM | 176 | 116 (5); 89 | 148 (7); 87 | < 0.001 | 135 (6); 88 | 129 (6); 88 | 0.24 | 132 | 25-345 | < 110 |
U-MDA/P-Uric acid; nM/mM × l -1 | 176 | 316 (14); 89 | 486 (22); 87 | < 0.001x | 373 (20); 88 | 397 (20); 88 | 0.19x | 385 | 74-1051 | < 375 |
All excretions ratesare per 2 h. If not otherwise indicated, data are mean values (SE). For further informations see text.
+: total number of patients; ++: number of patients in subgroups; *: creatinine; **: U and P indicate urine and plasma, respectively; x: based on log10; nd: not determined; 1: limits or range observed in 10 - 20 healthy adult male subjects in the authors' laboratory, and from literature.