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Efficacy of different classes of anti-HCV agents with respect to resistance profile, genotype coverage and antiviral activity
| NS3 Protease Inhibitors | NS5A Inhibitors | NS5B Nuc. Inhibitors | NS5B Non-Nuc. Inhibitors | Cyclophilin Inhibitors | PEG-Interferon alfa | |
|---|---|---|---|---|---|---|
| Barrier to resistance | low | low | high | low | high | very high |
| Genotype coverage | + | ++ | +++ | - | ++ | +++ |
| antiviral activity | +++ | +++ | ++ | ++ | +/++ | + |
