Table 2.
Delayed-type hypersensitivity test results for HIV controllers compared to non-controllers and HAART suppressors
| Characteristic | Elite Controllers | Viremic Controllers | HIV Controllers | Non- Controllers | P-value HIV Controllers vs. Non- Controllers | HAART Suppressors | P-value HIV Controllers vs. HAART Suppressors |
|---|---|---|---|---|---|---|---|
| Number of Participants, n | 33 | 116 | 149 | 3822 | - | 491 | - |
| DTH Test Results, All Participants | |||||||
| First DTH Test Resultsa | |||||||
| Non-anergic | 24 (72.7) | 98 (84.5) | 122 (81.9) | 2965 | 0.22 | 366 (74.5) | 0.07 |
| (77.6) | |||||||
| Partial Anergy | 5 (15.2) | 7 (6.0) | 12 (8.1) | 475 (12.4) | - | 62 (12.6) | - |
| Complete Anergy | 4 (12.1) | 11 (9.5) | 15 (10.1) | 382 (10.0) | - | 63 (12.8) | - |
| Average Percent of DTH Test Events Non-anergicb | 78.0 ± 31.3 (n = 33) | 82.0 ± 32.2 (n = 116) | 81.2 ± 31.9 (n = 149) | 70.7 ± 36.8 (n = 3822) | 0.0002 | - | - |
| Participants with CD4 200-399 cells/uL at DTH Testing | |||||||
| First DTH Test Results | |||||||
| Non-anergic | 1 (50.0) | 6 (75.0) | 7 (70.0) | 670 (74.2) | 0.76 | 52 (66.7) | 0.83 |
| Partial Anergy | 1 (50.0) | 1 (12.5) | 2 (20.0) | 138 (15.3) | - | 14 (17.9) | - |
| Complete Anergy | 0 (0) | 1 (12.5) | 1 (10.0) | 95 (10.5) | - | 12 (15.4) | - |
| Average Percent of DTH Test Events Non-anergic | 65.1 ± 57.7 (n = 3) | 85.8 ± 33.4 (n = 27) | 83.4 ± 35.6 (n = 30) | 71.9 ± 40.9 (n = 2116) | 0.15 | - | - |
| Participants with CD4 ≥ 400 cells/uL at DTH Testing | |||||||
| First DTH Testing Results | |||||||
| Non-anergic | 23 (74.2) | 91 (85.0) | 114 (82.6) | 1910 (84.7) | 0.52 | 306 (76.5) | 0.14 |
| Partial Anergy | 4 (12.9) | 6 (5.6) | 10 (7.2) | 222 (9.8) | - | 47 (11.8) | - |
| Complete Anergy | 4 (12.9) | 10 (9.3) | 14 (10.1) | 124 (5.5) | - | 47 (11.8) | - |
| Average Percent of DTH Test Events Non-anergic | 78.2 ± 31.5 (n = 32) | 82.0 ± 32.8 (n = 109) | 81.2 ± 31.5 (n = 141) | 80.4 ± 32.7 (n = 2705) | 0.76 | - | - |
NOTE. HIV controllers, combined group of elite and viremic controllers; HAART suppressors, subgroup of non-controllers on suppressive HAART; all values are number, percent or SD
a Non-anergic, ≥ 2 tests positive; partial anergy, 1 test positive; complete anergy, zero positive tests
b Weighted average of each participant's individual average. Weights based on number of measurements per subject and correlation of repeated DTH measurements