Table 2.
Odds of an endometriosis diagnosis by urinary concentrations of BP derivatives and cohort (ENDO Study)
| BP analyte | Operative cohort (n=473)
|
Population cohort (n=127)
|
||
|---|---|---|---|---|
| (quarter ng/mL) | OR c (95% CI) | OR d (95% CI) | OR c (95% CI) | OR d (95% CI) |
| 2OH-4MeO-BP | ||||
| 1st quartile (<0.28-2.43) | reference | reference | reference | reference |
| 2nd quartile (2.44-5.99) | 0.80 (0.47, 1.34) | 0.82 (0.48, 1.38) | 0.96 (0.12, 7.38) | 0.89 (0.11, 7.25) |
| 3rd quartile (6.00-36.69) | 0.96 (0.58, 1.61) | 0.99 (0.59, 1.67) | 1.92 (0.34, 10.8) | 2.36 (0.39, 14.2) |
| 4th quartile (36.70-5890) | 1.12 (0.67, 1.88) | 1.24 (0.73, 2.10) | 1.64 (0.29, 9.19) | 1.67 (0.28, 10.1) |
| Trend test a | 1.05 (0.89, 1.24) | 1.08 (0.92, 1.28) | 1.22 (0.73, 2.06) | 1.25 (0.73, 2.15) |
| >Q3 versus <Q3 b | 1.22 (0.79, 1.87) | 1.33 (0.85, 2.06) | 1.22 (0.38, 3.91) | 1.17 (0.34, 3.94) |
| 2,4OH-BP | ||||
| 1st quartile (<0.082-1.68) | reference | reference | reference | reference |
| 2nd quartile (1.69-5.65) | 0.77 (0.45, 1.31) | 0.76 (0.44, 1.31) | 0.44 (0.07, 2.89) | 0.48 (0.07, 3.40) |
| 3rd quartile (5.66-26.59) | 1.14 (0.68, 1.92) | 1.16 (0.68, 1.97) | 0.63 (0.13, 3.13) | 0.73 (0.14, 3.97) |
| 4th quartile (26.60-3200) | 1.43 (0.87, 2.35) | 1.59 (0.94, 2.66) | 0.86 (0.18, 4.03) | 0.89 (0.17, 4.61) |
| Trend test a | 1.15 (0.98, 1.35) | 1.19 (1.01, 1.41) | 1.02 (0.60, 1.74) | 1.03 (0.60, 1.79) |
| >Q3 versus <Q3 b | 1.48 (0.98, 2.25) | 1.65 (1.07, 2.53) | 1.33 (0.41, 4.27) | 1.25 (0.37, 4.24) |
| 4OH-BP | ||||
| 1st quartile (<0.082-0.17) | reference | reference | reference | reference |
| 2nd quartile (0.18-0.35) | 0.87 (0.52, 1.45) | 0.92 (0.55, 1.54) | 1.08 (0.20, 5.85) | 1.51 (0.25, 9.20) |
| 3rd quartile (0.36-0.71) | 1.02 (0.61, 1.71) | 1.03 (0.62, 1.73) | 1.24 (0.25, 6.06) | 2.20 (0.38, 12.7) |
| 4th quartile (0.71-22.40) | 0.84 (0.49, 1.42) | 0.87 (0.51, 1.48) | 1.16 (0.24, 5.66) | 1.69 (0.31, 9.21) |
| Trend test a | 0.97 (0.82, 1.14) | 0.97 (0.82, 1.15) | 1.06 (0.65, 1.73) | 1.19 (0.71, 1.98) |
| >Q3 versus <Q3 b | 0.87 (0.56, 1.36) | 0.89 (0.57, 1.38) | 1.05 (0.31, 3.58) | 1.12 (0.31, 4.01) |
NOTE: Logistic regression models for the operative cohort include 190 women with and 283 without endometriosis, and 14 and 113 women with and without endometriosis, respectively, in the population cohort.
a
Trend test assessed linear trends of BP derivatives across the four intervals defined by the 25th, 50th, and 75th percentiles.
b
Women in the highest quartile for each BP derivative were compared with women in the combined first three quartiles.
c
Odds ratios from unadjusted logistic regressions
d
Odds ratios from multivariable logistic regressions adjusting for site (Utah, California) and hair color (red, blonde, brown/black)