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Subject randomization
| Group | Name | Sample size | Compound | Dosage |
|---|---|---|---|---|
| A0 | Placebo | n = 15 | Placebo | N/A (CMC capsule b.i.d) |
| A1 | Dose 1 | n = 15 | UP446 | 250 mg/day (125 mg b.i.d.) |
| A2 | Dose 2 | n = 15 | UP446 | 500 mg/day (250 mg b.i.d.) |
| A3 | Dose 3 | n = 15 | Celecoxib | 200 mg/day (100 mg b.i.d.) |
Acetaminophen was provided as rescue medication. Subjects were permitted to take up to 1000 mg t.i.d.
