Table 1.
Pharmacokinetic properties of voriconazole and posaconazole.
| Property | Posaconazole | Voriconazole |
|---|---|---|
| Bioavailability | variable (depending on dosage regimen and food) |
> 95% |
| Protein binding | > 98% | 58% |
| Vd/F (L/kg) | 7-25 | 4.6 |
| Tmax (h) | 3-6 | 1-2 |
| Metabolism | hepatic: glucuronidation | hepatic: CYP2C19, 2C9, 3 A4 |
| T1/2 (h) | 15-35 | 6-24 |
| Elimination route | < 1% excreted unchanged in urine 66% excreted unchanged in faeces | hepatic; < 2% excreted unchanged in urine |
T1/2: elimination half life; tmax: time to reach the maximum plasma concentration; Vd/F: apparent volume of distribution after oral administration