Table 2.
Drug interactions with voriconazole.-
| Drug | Management |
|---|---|
| Decreases voriconazole interactions | |
| Rifampin | contraindicated |
| Rifabutin | contraindicated |
| Phenytoin | monitoring |
| Carbamazepine | contraindicated |
| Long-acting barbiturates | contraindicated |
| Ritonavir | contraindicated |
| Efavirenz | contraindicated |
| Increases in concentration by voriconazole | |
| Sirolimus | contraindicated |
| Rifabutin | contraindicated |
| Efavirenz | contraindicated |
| Quinidine | contraindicated |
| Tacrolimus | monitoring |
| Cyclosporine | monitoring |
| Omeprazole | reduce dose by half |
| Warfarin | monitoring |
| Methadone | reduce dose |
| Likely increases in concentration by voriconazole | |
| Ergot alkaloids | contraindicated |
| Pimozide | contraindicated |
| Sulfonylureas | monitoring |
| HMG-CoA reductase inhibitors | monitoring |
| Vinca alkaloids | monitoring |
| Calcium channel blockers | monitoring |
| Benzodiazepines | monitoring |
| Prednisolone | monitoring |
| HIV protease inhibitors, not indinavir | monitoring |