Table 4.

Drug interactions with Posaconazole.

Drug	Management
Concentration increased by posaconazole
Atazanavir	Monitoring
Cyclosporine	reduce dose
Lorazepam	contraindicated
Midazolam	reduce dose
Sirolimus	contraindicated
Tacrolimus	reduce dose
Concentration is increased by posaconazole/decreases posaconazole concentration
Phenytoin	avoid co-administration
Rifabutin	avoid co-administration
Decreases posaconazole concentration
Cimetidine	avoid co-administration
Efavirenz	avoid co-administration
Concentration may be increased by posaconazole
Alprazolam	reduce dose
Amiodarone	monitoring
Astemizole	contraindicated
Benzodiazepines	monitoring
Calcium channel blockers	monitoring
Carbamazepine	monitoring
Cisapride	contraindicated
Corticosteroid	monitoring
Digoxin	monitoring
Drugs for erectile dysfunction (e.g. sildenafil)	monitoring
Ergot alkaloids	contraindicated
HMG-CoA reductase inhibitors	monitoring
Irinotecan	monitoring
Quinidine	contraindicated
Sulfonylureas	monitoring
Terfenadine	reduce dose
Vinca alkaloids	monitoring
May decrease posaconazole concentrations
Famotidine	avoid co-administration
Omeprazole	avoid co-administration
Ranitidine	avoid co-administration
Rifampin	monitoring