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. 2012 Feb;2(2):110032. doi: 10.1098/rsob.110032

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© 2012 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Nuclear exclusion of Spc105, and initiation of Mis12 complex assembly in interphase by Spc105 kinetochore-binding domain. (a) Sub-cellular localization of EGFP::Spc105 and EGFP::Spc105-C throughout a cortical cleavage division. Full-length protein is excluded from the nucleus in interphase and accumulates in the nucleus in prophase. After mitosis, Spc105 is excluded from the nucleus. Spc105-C is not excluded from the nucleus in interphase but prophase accumulation is comparable with full-length protein. Scale bar 10 µm. (b) Recruitment of Spc105-C and Nsl1 to the interphase centromere. Nuclear import of Spc105-C in interphase is sufficient to recruit itself and Nsl1 to the centromere. This capacity of Spc105-C depends on the functionality of its nuclear localization signal. Scale bars, 10 µm.