Table 1.

Key Regulators of Triple-Negative Breast Cancer (TNBC) Identified by Enrichment Analysis of 4-fold Differentially Expressed Genes in TNBC Samples in Comparison with Normal Breast Tissue

Subnetwork Pathway	Size	Gene Set Seed	P value
AGT	363	AGT	8.87 × 10−7
NF-κB	659	NF-κB	1.37 × 10−6
PDGF	274	PDGF	2.35 × 10−6
TP53	465	TP53	2.48 × 10−6
CLSPN	1	CLSPN	4.75 × 10−5
Arachidonate 15-lipoxygenase	11	Arachidonate 15-lipoxygenase	6.71 × 10−5
CCL5	33	CCL5	8.35 × 10−5
TIRAP	12	TIRAP	8.68 × 10−5
CCL4	13	CCL4	1.099 × 10−4
FGF2	350	FGF2	1.312 × 10−4
IL1 family	284	IL1 family	1.365 × 10−4
MELK	2	MELK	1.419 × 10−4
MASTL	2	MASTL	1.419 × 10−4
ESR1	288	ESR1	1.517 × 10−4
IKBKB	39	IKBKB	1.595 × 10−4
IL22	39	IL22	1.595 × 10−4

AGT = angiotensinogen; ESR1 = estrogen receptor 1; FGF = fibroblast growth factor; IL = interleukin; PDGF = platelet-derived growth factor.