Table 3.
Metabolic Pathways Significantly Changed in Triple-Negative Breast Cancer by Gene Set Enrichment Analysis
| Pathway | Size | Gene Set Seed | P value |
|---|---|---|---|
| Purine metabolism | 151 | 1.04794 | 2.76 × 10−5 |
| Folate biosynthesis | 70 | 1.32692 | 0.000742 |
| Pyrimidine metabolism | 106 | 1.11415 | 0.001049 |
| Biosynthesis of cholesterol | 83 | 1.13374 | 0.002436 |
| Amino sugars synthesis | 57 | 1.33648 | 0.002488 |
| Respiratory chain and oxidative phosphorylation | 34 | 1.16559 | 0.003506 |
| Tryptophan metabolism | 110 | 1.03413 | 0.004232 |
| Nicotinate and nicotinamide metabolism | 46 | 1.03603 | 0.011342 |
| Lysine metabolism | 74 | −1.00047 | 0.012182 |
| Tricarboxylic acid cycle | 55 | 1.07236 | 0.014528 |
| Bile acids metabolism | 70 | −1.03581 | 0.020433 |
| Urea cycle and arginine metabolism | 86 | −1.03614 | 0.022182 |
| Phenylalanine and tyrosine metabolism | 103 | −1.00657 | 0.025452 |
| Ser/Gly/Thr/Cys metabolism | 133 | 1.01691 | 0.026181 |
| Histidine metabolism | 48 | −1.08427 | 0.040691 |