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. 2011 Sep;2(9):880–888. doi: 10.1177/1947601911433129

Figure 3.

Figure 3.

HOXC8-CDH11 axis promotes endogenous Rac activity in breast cancer cells. (A) Hs578T and MDA-MB-231 cells lentivirally expressing scramble sequence or CDH11 shRNAs were analyzed for Rac, Cdc42, and RhoA activities as described in Materials and Methods. Cell lysates were also collected and subjected to immunoblotting to detect CDH11 and β-actin. (B) HOXC8-knockdown Hs578T or MDA-MB-231 cells were forced to express CDH11 transgene and then analyzed for Rac activities. Cell lysates were also collected and subjected to immunoblotting to detect HOXC8, CDH11, and β-actin.