Table 5.
Effect of rutin (RT) and/or ascorbic acid (AA) on kidney nucleic acids and total protein levels in high-cholesterol diet (HCD) fed rats following 6 weeks of supplementation
| Treatment (in rat chow) |
DNA (μg/100 mg) | RNA (μg/100 mg) | Total protein (mg/100 mg) | |||
|---|---|---|---|---|---|---|
| Male | Female | Male | Female | Male | Female | |
| Control | 101.35 ± 18.33 | 110.56 ± 17.93 | 266.30 ± 26.60 | 240.16 ± 19.00 | 12.21 ± 0.47 | 11.26 ± 0.63 |
| RT (0.2%) | 108.33 ± 24.25 | 117.22 ± 12.08 | 271.22 ± 27.50 | 254.10 ± 11.80 | 12.15 ± 0.49 | 11.63 ± 0.43 |
| AA (0.4%) | 110.25 ± 18.05 | 114.21 ± 21.35 | 278.77 ± 17.28 | 248.52 ± 13.58 | 11.84 ± 0.53 | 11.95 ± 0.24 |
| RT (0.1%) + AA (0.2%) | 114.35 ± 17.37 | 112.60 ± 21.77 | 269.24 ± 31.53 | 250.20 ± 13.05 | 12.20 ± 0.60 | 11.53 ± 0.56 |
| HCD (1% cholesterol + 0.5% cholic acid) | 76.07 ± 15.99 | 75.64 ± 16.37 a | 247.01 ± 13.17 | 186.95 ± 19.04 a | 11.45 ± 0.35 | 10.64 ± 0.35 |
| RT (0.2%) + HCD | 81.45 ± 10.83 b | 79.63 ± 12.47 ab | 252.52 ± 20.72 | 192.11 ± 13.22 ab | 11.54 ± 0.28 | 10.80 ± 0.31 b |
| AA (0.4%) + HCD | 79.62 ± 11.54 c | 84.46 ± 9.00 ac | 255.66 ± 18.87 | 193.82 ± 20.91 ac | 11.76 ± 0.37 | 10.96 ± 0.15 c |
| RT (0.1%) + AA (0.2%) + HCD | 86.64 ± 11.89 d | 102.49 ± 14.25 e | 258.09 ± 21.65 | 219.12 ± 15.86 ade | 11.87 ± 0.31 | 11.15 ± 0.24 |
Data were expressed as Mean ± S.D and analyzed using one-way ANOVA followed by Student Newman-Keuls method as post hoc test. Six rats were used in each group. aAll treated groups vs. Control; bRT + HCD vs RT group; cAA + HCD vs AA group; dRT + AA + HCD vs RT + AA group; eRT + HCD, AA + HCD and RT + AA + HCD vs HCD