Table 6.
Effect of rutin (RT) and/or ascorbic acid (AA) on kidney MDA and GSH levels in high-cholesterol diet (HCD) fed rats following 6 weeks of supplementation
| Treatment (in rat chow) |
MDA (mmol/g) | GSH (nmol/100 mg) | ||
|---|---|---|---|---|
| Male | Female | Male | Female | |
| Control | 168.77 ± 22.10 | 178.80 ± 15.99 | 131.68 ± 14.04 | 110.84 ± 18.16 |
| RT (0.2%) | 175.40 ± 19.88 | 184.13 ± 25.61 | 129.19 ± 9.45 | 122.87 ± 24.24 |
| AA (0.4%) | 164.19 ± 18.62 | 186.53 ± 25.54 | 128.14 ± 15.03 | 125.35 ± 39.96 |
| RT (0.1%) + AA (0.2%) | 161.67 ± 12.66 | 185.44 ± 29.42 | 126.87 ± 12.26 | 134.76 ± 15.95 |
| HCD (1% cholesterol + 0.5% cholic acid) | 204.91 ± 26.35 a | 253.80 ± 15.06 a | 94.93 ± 11.91 a | 79.56 ± 11.65 |
| RT (0.2%) + HCD | 194.50 ± 18.43 | 235.69 ± 11.26 ab | 98.29 ± 9.85 ab | 82.71 ± 13.96 b |
| AA (0.4%) + HCD | 182.48 ± 14.50 | 230.15 ± 13.94 ac | 101.28 ± 12.98 ace | 91.79 ± 12.32 |
| RT (0.1%) + AA (0.2%) + HCD | 164.44 ± 16.49 | 220.06 ± 16.02 ade | 117.71 ± 14.37 e | 106.01 ± 19.25 |
Data were expressed as Mean ± S.D and analyzed using one-way ANOVA followed by Student Newman-Keuls method as post hoc test. Six rats were used in each group. aAll treated groups vs. Control; bRT + HCD vs RT group; cAA + HCD vs AA group; dRT + AA + HCD vs RT + AA group; eRT + HCD, AA + HCD and RT + AA + HCD vs HCD