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. 2012 Apr 13;10:35. doi: 10.1186/1741-7015-10-35

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Copyright ©2012 Aboud et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Neuron size and number in epilepsy relative to APOE genotype An apparent larger size of neurons (arrows) in patients with APOE ε3,3 (A) relative to those in patients with APOE ε4,4 (B) genotype was confirmed by computer assisted area measurements of individual neurons (APOE ε3,3 = 356 ± 45 μm²vs APOE ε4,4 = 173 ± 27 μm²; P < 0.001) (C and D). However, the numbers of neurons per image were similar for both genotypes (APOE ε3,3 = 21.5 ± 3.1 vs APOE ε4,4 = 24.0 ± 1.8; P = 0.18) (E and F).