Cytoplasm
Reduced
1. Cancer, Gastrointestinal Disease, Genetic Disorder	58
2. Cellular Assembly and Organization, Protein Synthesis, Cell Death
3. Protein Synthesis, Cancer, Gastrointestinal Disease	30
4. Connective Tissue Disorders, Infammatory Disease, Skeletal and Muscular Disorders	25
5. Cell Morphology, Cardiovascular System Development and Function, Gene Expression	23
Oxidized
1. Cancer, Cellular Function and Maintenance, Embryonic Development	51
2. Cell Signaling, Post-Translational Modifcation, Protein Folding	39
3. Post-Translational Modifcation, Protein Folding, Cellular Compromise	37
4. Cellular Compromise, Cellular Development, Embryonic Development	31
5. Gene Expression, Cellular Assembly and Organization, Connective Tissue Disorders	22
Nuclei
Reduced
1. RNA Post-Transcriptional Modifcation, Gene Expression, Infection Mechanism	32
2. Molecular Transport, RNA Traffcking, Cellular Compromise	26
Oxidized
1. Cellular Assembly and Organization, Cancer, Cell Morphology	35
2. RNA Post-Transcriptional Modifcation, Cellular Assembly and Organization, Cellular Movement	35
Mitochondria
Reduced
1. Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry	24
2. Genetic Disorder, Metabolic Disease, Cancer	14
Oxidized
Cellular Function and Maintenance, Cell Cycle, Reproductive System Development and Function	36

IPA-calculated signifcant score for each network is generated using a p-value calculation, and is displayed as the negative log of that p-value. This score indicates the likelihood that the assembly of a set of focus genes in a network could be explained by random chance alone. (Note provided by IPA: A score of 2 indicates that there is a 1 in 100 chance that the focus genes are together in a network due to random chance. Therefore, networks with scores of 2 or higher have at least a 99% confdence of not being generated by random chance alone. http://www.ingenuity.com/products/Monarch.NovelMolecularMechanisms_high.pdf)