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History of the introduction of antimalarial drugs and the first detection of resistance in the field. The following abbreviations are used: CQ, chloroquine; PG, proguanil; Pyr, pyrimethamine; SP, sulphadoxine–pyrimethamine; Mef, mefloquine; Hal, halofantrine; ACTs, artemisinin combination therapies; Ato, atovaquone; Ato-PG, atovaquone–proguanil combination (malarone); LD, LapDap (chlorproguanil–dapsone). R as suffix denotes resistance. Figure redrawn from Hyde (2005).
