Figure 4.

Automated PRIA-based diagnosis of pluripotency in teratomas. (a) Pathologist assessment for evidence of mesoderm, ectoderm, and endoderm morphogenesis: muscle (+), nervous tissue (*), and epithelium (←) are labeled in a teratoma. (b) Represents the same image in (a) after PRIA [Teratoma 1, Table 1]. Pseudo-color mark-up illustrates muscle (green), nervous tissue (yellow), cartilage (blue), and epithelium (red), evidence of pluripotency. PRIA diagnostic agreement was accepted if all of the tissue classes representing all germ layers (as in this example), were identified with >50% sensitivities. Bars=500um