Figure 5.

Teratoma phenotypic diversity highlighted challenges developing PRIA algorithms. (a, b, same field of view). Agreement with pathologist assessment of pluripotency by PRIA using Teratoma 2 algorithm for less-differentiated teratomas was documented in (b) by evidence of mesoderm (bone, brown; connective tissue, green), endoderm (epithelia, red), and ectoderm (nervous tissue, pink). However, more-differentiated teratomas (c, d, same field of view) were less accurately segmented. For example, large areas of muscle (†) and nervous tissue (*) were misidentified as connective tissue (green). 200 μm