Table 3.
Primary target values and parameter settings (absolute numbers and percent (%) in parenthesis)
| Germany | Austria | Switzerland | All countries | Differences between countries | |
|---|---|---|---|---|---|
| N = 153 | N = 11 | N = 26 | N = 190 | p-value | |
| Oxygen therapy | |||||
| FiO2 | |||||
| 0.21 | 47/147 (32) | 1/11 (9) | 8/25 (32) | 56/183 (31) | |
| 0.22 - 0.5 | 81/147 (55) | 10/11 (91) | 14/25 (56) | 105/183 (57) | 0.241 |
| 0.51 - 1.0 | 19/147 (13) | 0/11 (0) | 3/25 (12) | 3/183 (12) | |
| Target SpO2 | |||||
| < 85% | 21/145 (14) | 1/7 (14) | 8/24 (33) | 30/176 (17) | |
| 85-90% | 108/145 (74) | 5/7 (71) | 13/24 (54) | 126/176 (72) | 0.231 |
| > 90% | 16/145 (11) | 1/7 (14) | 3/24 (13) | 20/176 (11) | |
| High FiO2, taper down | 31/152 (20) | 2/11 (18) | 2/25 (20) | 38/188 (20) | |
| Low FiO2, taper up | 12/152 (80) | 9/11 (82) | 20/25 (80) | 150/188 (80) | 0.984 |
| Non-invasive respiratory support | |||||
| Prolonged inflations | 41/148 (28) | 3/11 (27) | 3/25 (12) | 47/184 (26) | 0.248 |
| > 5 sec | |||||
| Starting CPAP | |||||
| ≤ 3 cmH20 | 9/149 (6) | 0/0 (0) | 1/21 (5) | 10/180 (6) | |
| 4-5 cmH20 | 114/149 (77) | 6/10 (60) | 19/21 (90) | 139/180 (77) | 0.170 |
| > 5 cmH20 | 26/149 (17) | 4/10 (40) | 1/21 (5) | 31/180 (17) | |
| Invasive respiratory support | |||||
| INSURE yes | 43/142 (30) | 4/9 (44) | 4/19 (21) | 51/170 (30) | 0.444 |
| Surfactant | |||||
| 100 mg/kg | 129/145 (89) | 3/7 (43) | 11/14 (79) | 143/166 (86) | 0.002 |
| 150-200 mg/kg | 16/145 (11) | 4/7 (57) | 3/14 (21) | 23/166 (14) | |
FiO2 = fraction of inspired oxygen
CPAP = continuous positive airway pressure
INSURE = intubate, surfactant application, extubate immediately
SpO2 = peripheral saturation of oxygen