. Author manuscript; available in PMC: 2013 Apr 1.

Published in final edited form as: Breast Cancer Res Treat. 2012 Jan 3;132(3):1119–1126. doi: 10.1007/s10549-011-1938-8

Table 2.

SNP genotype distribution and association with breast cancer risk. Analysis restricted to mutation carriers of European ancestry

Mutation	Genotype	Unaffected, N (%)	Affected^a, N (%)	HR	95% CI	P value
BRCA1	GG	1,941 (71.3)	2,160 (71.5)	1
	AG	701 (25.8)	775 (25.7)	1.02	0.91–1.14
	AA	79 (2.9)	85 (2.8)	1.06	0.79–1.41
	2-df test					0.90
	Per-allele			1.02	0.93–1.12	0.66
BRCA2	GG	909 (61.1)	1,201 (64.9)	1
	AG	504 (33.9)	589 (31.8)	0.96	0.83–1.10
	AA	76 (5.1)	60 (3.2)	0.75	0.53–1.05
	2-df test					0.24
	Per-allele			0.92	0.82–1.04	0.17

Breast cancer