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. 2012 May 15;7(5):e35237. doi: 10.1371/journal.pone.0035237

Table 1. Markers showing near-significant and significant association with bFGF-induced corneal neovascularization in a 77-animal C57BL/6J×129P1/ReJ F2 cross.

Marker Chrom. cM b0 b1 F % P
D1Mit218 1 67 0.708 0.19 8.979 11% 0.004 **
D2Mit396 2 69 0.712 0.119 2.805 4% 0.098
D7Mit76 7 3.4 0.713 −0.173 6.807 8% 0.011 *
D7Mit246 7 15 0.707 −0.193 10.01 12% 0.002 **
D7Mit229 7 23 0.706 −0.189 10.05 12% 0.002 **
D7Mit201 7 37 0.702 −0.184 8.595 10% 0.004 **
D7Mit253 7 53 0.709 −0.181 6.933 8% 0.01 *
D7Mit105 7 64 0.715 −0.162 5.062 6% 0.027 *
D10Mit298 10 3 0.715 0.151 5.028 6% 0.028 *
D11Mit78 11 2 0.727 0.128 4.167 5% 0.045 *
D12Mit150 12 59 0.707 0.123 3.775 5% 0.056
D14Mit152 14 15 0.708 0.129 3.006 4% 0.087
D14Mit234 14 23 0.692 0.203 7.634 9% 0.007 **
D14Mit30 14 29 0.699 0.191 7.504 9% 0.008 **
D14Mit39 14 30 0.699 0.191 7.504 9% 0.008 **
D14Mit228 14 46 0.697 0.151 5.072 6% 0.027 *
D16Mit139 16 43 0.706 −0.14 3.512 4% 0.065
D17Mit155 17 56 0.719 0.118 3.193 4% 0.078
D19Mit128 19 11 0.715 0.144 3.88 5% 0.053
DXMit166 20 16 0.708 −0.11 3.984 5% 0.05 *
DXMit186 20 69 0.702 −0.139 6.54 8% 0.013 *

Marker = marker tested; Chr. = chromosome the marker is on; % = fraction of the experimental variance attributable to genotype at the marker indicated under an additive model; P = likelihood that there is no relationship between the marker genotype and choroidal neovascularization area (by F test), when the data are fit to the simple linear regression model y = b0+b1×+e. The results give the estimates for b0, b1 and the F statistic for each marker. b0 is approximately the average area of C57BL/6J-allele-containing strains. b1 is an indication of the effect of substitution of the 129P1/ReJ allele at that marker. Asterisks indicate uncorrected P<0.05 (*), P<0.01 (**), or P<0.001 (***).