Table 1. Markers showing near-significant and significant association with bFGF-induced corneal neovascularization in a 77-animal C57BL/6J×129P1/ReJ F2 cross.
Marker | Chrom. | cM | b0 | b1 | F | % | P | |
D1Mit218 | 1 | 67 | 0.708 | 0.19 | 8.979 | 11% | 0.004 | ** |
D2Mit396 | 2 | 69 | 0.712 | 0.119 | 2.805 | 4% | 0.098 | |
D7Mit76 | 7 | 3.4 | 0.713 | −0.173 | 6.807 | 8% | 0.011 | * |
D7Mit246 | 7 | 15 | 0.707 | −0.193 | 10.01 | 12% | 0.002 | ** |
D7Mit229 | 7 | 23 | 0.706 | −0.189 | 10.05 | 12% | 0.002 | ** |
D7Mit201 | 7 | 37 | 0.702 | −0.184 | 8.595 | 10% | 0.004 | ** |
D7Mit253 | 7 | 53 | 0.709 | −0.181 | 6.933 | 8% | 0.01 | * |
D7Mit105 | 7 | 64 | 0.715 | −0.162 | 5.062 | 6% | 0.027 | * |
D10Mit298 | 10 | 3 | 0.715 | 0.151 | 5.028 | 6% | 0.028 | * |
D11Mit78 | 11 | 2 | 0.727 | 0.128 | 4.167 | 5% | 0.045 | * |
D12Mit150 | 12 | 59 | 0.707 | 0.123 | 3.775 | 5% | 0.056 | |
D14Mit152 | 14 | 15 | 0.708 | 0.129 | 3.006 | 4% | 0.087 | |
D14Mit234 | 14 | 23 | 0.692 | 0.203 | 7.634 | 9% | 0.007 | ** |
D14Mit30 | 14 | 29 | 0.699 | 0.191 | 7.504 | 9% | 0.008 | ** |
D14Mit39 | 14 | 30 | 0.699 | 0.191 | 7.504 | 9% | 0.008 | ** |
D14Mit228 | 14 | 46 | 0.697 | 0.151 | 5.072 | 6% | 0.027 | * |
D16Mit139 | 16 | 43 | 0.706 | −0.14 | 3.512 | 4% | 0.065 | |
D17Mit155 | 17 | 56 | 0.719 | 0.118 | 3.193 | 4% | 0.078 | |
D19Mit128 | 19 | 11 | 0.715 | 0.144 | 3.88 | 5% | 0.053 | |
DXMit166 | 20 | 16 | 0.708 | −0.11 | 3.984 | 5% | 0.05 | * |
DXMit186 | 20 | 69 | 0.702 | −0.139 | 6.54 | 8% | 0.013 | * |
Marker = marker tested; Chr. = chromosome the marker is on; % = fraction of the experimental variance attributable to genotype at the marker indicated under an additive model; P = likelihood that there is no relationship between the marker genotype and choroidal neovascularization area (by F test), when the data are fit to the simple linear regression model y = b0+b1×+e. The results give the estimates for b0, b1 and the F statistic for each marker. b0 is approximately the average area of C57BL/6J-allele-containing strains. b1 is an indication of the effect of substitution of the 129P1/ReJ allele at that marker. Asterisks indicate uncorrected P<0.05 (*), P<0.01 (**), or P<0.001 (***).