Figure 5. MYOC mutants altered most physiological biomarkers of glaucoma.

Heat maps of a gene list containing 50 potential biomarkers for the human trabecular meshwork (Table S6). The biomarker gene list was generated by a comprehensive review of trabecular meshwork expression studies as indicated in the result section. Each row represents the fold change (Adeno.MYOC mutant over Adeno.Null) for a single gene in each of the four mutants. Each column represents the fold changes for all biomarkers in one MYOC mutant. The fold change for each gene is visually represented by a color, which is given by the scale bar at left. Heat maps were generated with genes lists containing the full range of fold changes. Gray cells indicate that the expression of the giving gene was below the cutoff of signal intensity value and was considered absent.