Table 2. Screening of 34 small bioactive compounds.
REFERENCE COMPOUNDS | FAMILY | CARDIAC EFFECT IN HUMANS | CARDIOTOXIC EFFECT IN ZEBRAFISH | CLASSIFICATION |
Lidocaine | Antiarrhythmic | Bradycardia | Bradycardia | TP |
Flecainide | Antiarrhythmic | QT-prolong. | Arrhythmia 2∶1 | TP |
Propafenone | Antiarrhythmic | QT-prolong. | Arrhythmia 2∶1 | TP |
Amiodarone | Antiarrhythmic | QT-prolong. | Arrhythmia 2∶1 | TP |
Propranolol | Beta-Blocker | Bradycardia | Bradycardia | TP |
Timolol | Beta-Blocker | Bradycardia | Bradycardia | TP |
Thioridazine | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
Haloperidol | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
Ziprasidone | Antipsychotic | QT-prolong. | Bradycardia | FN |
Pimozide | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
Sertindol | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
Risperidone | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
Fluoxetine | Antidepressant | Arrhythmia | Arrhythmia | TP |
Doxorrubicin | Antitumoral | No effect | No effect | TN |
Tamoxifen | Antitumoral | Arrhythmia | Arrhythmia | TP |
Lapatinib | Antitumoral | No effect | No effect | TN |
Verapamil | Calcium blocker | Bradycardia | Bradycardia | TP |
Diltiazem | Calcium blocker | Bradycardia | Bradycardia | TP |
Nitrendipine | Calcium blocker | Cardiac arrest | Cardiac arrest | TP |
Terodiline | Calcium blocker | QT-prolong. | Arrhythmia 2∶1 | TP |
Pilocarpine | Colinergic agonist | No effect | No effect | TN |
Nicotine | Colinergic agonist | Bradycardia | Bradycardia | TP |
Astemizol | Antihistamine | QT-prolong. | Arrhythmia 2∶1 | TP |
Terfenadine | Antihistamine | QT-prolong. | Arrhythmia 2∶1 | TP |
Fexofenadine | Antihistamine | No effect | No effect | TN |
Halofantrine | Antiinfective | QT-prolong. | Arrhythmia 2∶1 | TP |
Foscarnet | Antiinfective | Bradycardia | Bradycardia | TP |
Cisapride | Gastrointestinal agent | QT-prolong. | Arrhythmia 2∶1 | TP |
Estradiol | Hormones | Bradycardia | Bradycardia | TP |
Testosterone | Hormones | Bradycardia | Bradycardia | TP |
L-768763 | Iks blocker | QT-prolong. | Bradycardia | FN |
Chromanol 293b | Iks blocker | QT-prolong. | No effect | FN |
SDZ-201106 | Ina opener | QT-prolong. | Arrhythmia 2∶1 | TP |
Digitoxin | Other | Bradycardia | Cardiac arrest | TP |
Ketanserin | Other | Bradycardia | Bradycardia | TP |
The table shows the compounds used for validation, their family and their cardiotoxic effects assessed in humans and zebrafish.TN (true negative), TP (true positive), FN (false negative), FP (false positive).