Table 2. Screening of 34 small bioactive compounds.
| REFERENCE COMPOUNDS | FAMILY | CARDIAC EFFECT IN HUMANS | CARDIOTOXIC EFFECT IN ZEBRAFISH | CLASSIFICATION |
| Lidocaine | Antiarrhythmic | Bradycardia | Bradycardia | TP |
| Flecainide | Antiarrhythmic | QT-prolong. | Arrhythmia 2∶1 | TP |
| Propafenone | Antiarrhythmic | QT-prolong. | Arrhythmia 2∶1 | TP |
| Amiodarone | Antiarrhythmic | QT-prolong. | Arrhythmia 2∶1 | TP |
| Propranolol | Beta-Blocker | Bradycardia | Bradycardia | TP |
| Timolol | Beta-Blocker | Bradycardia | Bradycardia | TP |
| Thioridazine | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
| Haloperidol | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
| Ziprasidone | Antipsychotic | QT-prolong. | Bradycardia | FN |
| Pimozide | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
| Sertindol | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
| Risperidone | Antipsychotic | QT-prolong. | Arrhythmia 2∶1 | TP |
| Fluoxetine | Antidepressant | Arrhythmia | Arrhythmia | TP |
| Doxorrubicin | Antitumoral | No effect | No effect | TN |
| Tamoxifen | Antitumoral | Arrhythmia | Arrhythmia | TP |
| Lapatinib | Antitumoral | No effect | No effect | TN |
| Verapamil | Calcium blocker | Bradycardia | Bradycardia | TP |
| Diltiazem | Calcium blocker | Bradycardia | Bradycardia | TP |
| Nitrendipine | Calcium blocker | Cardiac arrest | Cardiac arrest | TP |
| Terodiline | Calcium blocker | QT-prolong. | Arrhythmia 2∶1 | TP |
| Pilocarpine | Colinergic agonist | No effect | No effect | TN |
| Nicotine | Colinergic agonist | Bradycardia | Bradycardia | TP |
| Astemizol | Antihistamine | QT-prolong. | Arrhythmia 2∶1 | TP |
| Terfenadine | Antihistamine | QT-prolong. | Arrhythmia 2∶1 | TP |
| Fexofenadine | Antihistamine | No effect | No effect | TN |
| Halofantrine | Antiinfective | QT-prolong. | Arrhythmia 2∶1 | TP |
| Foscarnet | Antiinfective | Bradycardia | Bradycardia | TP |
| Cisapride | Gastrointestinal agent | QT-prolong. | Arrhythmia 2∶1 | TP |
| Estradiol | Hormones | Bradycardia | Bradycardia | TP |
| Testosterone | Hormones | Bradycardia | Bradycardia | TP |
| L-768763 | Iks blocker | QT-prolong. | Bradycardia | FN |
| Chromanol 293b | Iks blocker | QT-prolong. | No effect | FN |
| SDZ-201106 | Ina opener | QT-prolong. | Arrhythmia 2∶1 | TP |
| Digitoxin | Other | Bradycardia | Cardiac arrest | TP |
| Ketanserin | Other | Bradycardia | Bradycardia | TP |
The table shows the compounds used for validation, their family and their cardiotoxic effects assessed in humans and zebrafish.TN (true negative), TP (true positive), FN (false negative), FP (false positive).